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Pomc Gene Detail
Summary
  • Symbol
    Pomc
  • Name
    pro-opiomelanocortin-alpha
  • Synonyms
    ACTH, adrenal corticotropic hormone, alpha-melanocyte stimulating hormone, alpha-MSH, alphaMSH, BE, beta-endorphin, beta-melanocyte stimulating hormone, beta-MSH, gamma-melanocyte stimulating hormone, gamma-MSH, POMC, Pomc-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97742
    NCBI Gene: 18976
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4004951-4010642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 1.99 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97742
 protein coding gene Chr12:4004945-4010643 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019561
 protein coding gene Chr12:804474-810135 (+)
A/J MGP_AJ_G0019528
 protein coding gene Chr12:832784-838451 (+)
AKR/J MGP_AKRJ_G0019498
 protein coding gene Chr12:975411-981072 (+)
BALB/cJ MGP_BALBcJ_G0019503
 protein coding gene Chr12:861698-867365 (+)
C3H/HeJ MGP_C3HHeJ_G0019309
 protein coding gene Chr12:760268-765930 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019952
 protein coding gene Chr12:824381-830048 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017577
 protein coding gene Chr12:745355-751076 (+)
CAST/EiJ MGP_CASTEiJ_G0018864
 protein coding gene Chr12:822932-828599 (+)
CBA/J MGP_CBAJ_G0019280
 protein coding gene Chr12:1067835-1073515 (+)
DBA/2J MGP_DBA2J_G0019393
 protein coding gene Chr12:774970-780637 (+)
FVB/NJ MGP_FVBNJ_G0019383
 protein coding gene Chr12:802014-807669 (+)
LP/J MGP_LPJ_G0019464
 protein coding gene Chr12:823708-829373 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019417
 protein coding gene Chr12:874970-880625 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019991
 protein coding gene Chr12:761057-766728 (+)
PWK/PhJ MGP_PWKPhJ_G0018630
 protein coding gene Chr12:789788-797744 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018421
 protein coding gene Chr12:837148-845170 (+)
WSB/EiJ MGP_WSBEiJ_G0018916
 protein coding gene Chr12:792091-797766 (+)



Homology
more
  • Human Ortholog
    POMC, proopiomelanocortin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POMC, proopiomelanocortin
  • Synonyms
    ACTH, CLIP, LPH, MSH, NPP, OBAIRH, POC
  • Links
    NCBI Gene ID: 5443
    neXtProt AC: NX_P01189
    UniProt: P01189

  • Chr Location
    2p23.3; chr2:25160853-25168903 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pomc mouse models; 6 with human POMC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    77 phenotypes from 8 alleles in 16 genetic backgrounds
    11 phenotypes from multigenic genotypes
    1 images
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are obese and exhibit abnormal hormone levels, abnormal pigmentation, increased food intake, and adiposity. Mice homozygous for another knock-out allele exhibit altered reward based behavior and immune response toLPS treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1284
  • Tissues
    287
  • cDNA Data
    79
  • Literature Summary
    202
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020660 Ensembl Gene Model | MGI Sequence Detail 5692 C57BL/6J ±  kb
    transcript ENSMUST00000219543 Ensembl | MGI Sequence Detail 1043 Not Applicable  
    polypeptide ENSMUSP00000151504 Ensembl | MGI Sequence Detail 235 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 123
      Genomic 8
      cDNA 87
      Primer pair 16
      Other 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13580, MGD-MRK-13582
    References
    more
    • Summaries
      All 455
      Developmental Gene Expression 202
      Diseases 1
      Gene Ontology 13
      Phenotypes 95
    • Earliest
      J:21792 Civelli O, et al., Detection and quantitation of pro-opiomelanocortin mRNA in pituitary and brain tissues from different species. J Biol Chem. 1982 Jun 25;257(12):6783-7
    • Latest
      J:353361 Yu H, et al., The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice. Mol Metab. 2024 Sep;87:101993
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory