Ppic MGI Mouse Gene Detail - MGI:97751 - peptidylprolyl isomerase C

Symbol

Ppic
Name

peptidylprolyl isomerase C
Synonyms

cyclophilin C, CyP-20c

Feature Type

protein coding gene
IDs

MGI:97751
NCBI Gene: 19038
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:53539413-53551079 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 29.03 cM, cytoband D1
Mapping Data

1 experiment

SNPs within 2kb

409 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97751	protein coding gene	Chr18:53539404-53551187 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024435	protein coding gene	Chr18:52584738-52597459 (-)
A/J	MGP_AJ_G0024401	protein coding gene	Chr18:50546879-50558580 (-)
AKR/J	MGP_AKRJ_G0024371	protein coding gene	Chr18:51957894-51969552 (-)
BALB/cJ	MGP_BALBcJ_G0024401	protein coding gene	Chr18:50732513-50745630 (-)
C3H/HeJ	MGP_C3HHeJ_G0024168	protein coding gene	Chr18:52102069-52115383 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024847	protein coding gene	Chr18:54340066-54352722 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022279	protein coding gene	Chr18:50323316-50334983 (-)
CAST/EiJ	MGP_CASTEiJ_G0023642	protein coding gene	Chr18:52075536-52087167 (-)
CBA/J	MGP_CBAJ_G0024138	protein coding gene	Chr18:55944372-55958255 (-)
DBA/2J	MGP_DBA2J_G0024268	protein coding gene	Chr18:50251938-50263834 (-)
FVB/NJ	MGP_FVBNJ_G0024235	protein coding gene	Chr18:49679226-49690855 (-)
LP/J	MGP_LPJ_G0024353	protein coding gene	Chr18:52604890-52616610 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024265	protein coding gene	Chr18:57679743-57694162 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024894	protein coding gene	Chr18:51990246-52003703 (-)
PWK/PhJ	MGP_PWKPhJ_G0023386	protein coding gene	Chr18:50267484-50279515 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023192	protein coding gene	Chr18:52164109-52175621 (-)
WSB/EiJ	MGP_WSBEiJ_G0023705	protein coding gene	Chr18:51907992-51924792 (-)

Human Ortholog

PPIC, peptidylprolyl isomerase C

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPIC, peptidylprolyl isomerase C
Synonyms

CYPC
Links

HGNC:9256

NCBI Gene ID: 5480

neXtProt AC: NX_P45877

UniProt: P45877
Chr Location

5q23.2; chr5:123023250-123036725 (-) GRCh38

MGI Vertebrate Homology

Ppic stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PPIC
Gene Tree

Ppic

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

2
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Ppic
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

less

All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

69
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppic

less

All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS29252.1

Ensembl

ENSMUSG00000024538 (Evidence)
NCBI Gene

19038

			Length	Strain/Species	Flank
genomic	19038	NCBI Gene Model \| MGI Sequence Detail	11667	C57BL/6J	± kb
transcript	NM_008908	RefSeq \| MGI Sequence Detail	1286	C57BL/6
polypeptide	P30412	UniProt \| EBI \| MGI Sequence Detail	212	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000013077 eukaryotic-type peptidyl-prolyl cis-trans isomerase C

(term hierarchy)
PDB

2RMC
EC

5.2.1.8
InterPro Domains

IPR029000 Cyclophilin-like domain superfamily

IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site

IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain

less

All nucleic 69

cDNA 69

Microarray probesets 3

less

MGD-MRK-13593

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 6
Earliest

J:17287 Friedman J, et al., Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA. Cell. 1991 Aug 23;66(4):799-806
Latest

J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67

TSS for Ppic:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153330	Chr18:53551127-53551138 (-)	-54 bp
Tssr153329	Chr18:53551076-53551116 (-)	-17 bp
Tssr153328	Chr18:53551037-53551075 (-)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24