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Srgn Gene Detail
Summary
  • Symbol
    Srgn
  • Name
    serglycin
  • Synonyms
    Prg1, Sgc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97756
    NCBI Gene: 19073
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62329612-62363224 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.42 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    847 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97756
 protein coding gene Chr10:62329612-62363230 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017300
 protein coding gene Chr10:61925723-61960069 (-)
A/J MGP_AJ_G0017278
 protein coding gene Chr10:60031139-60066493 (-)
AKR/J MGP_AKRJ_G0017238
 protein coding gene Chr10:61596653-61630077 (-)
BALB/cJ MGP_BALBcJ_G0017238
 protein coding gene Chr10:60114101-60149414 (-)
C3H/HeJ MGP_C3HHeJ_G0017061
 protein coding gene Chr10:61516829-61551213 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017696
 protein coding gene Chr10:64144006-64179652 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015386
 protein coding gene Chr10:56997231-57031452 (-)
CAST/EiJ MGP_CASTEiJ_G0016632
 protein coding gene Chr10:61566234-61602422 (-)
CBA/J MGP_CBAJ_G0017033
 protein coding gene Chr10:66549265-66592247 (-)
DBA/2J MGP_DBA2J_G0017138
 protein coding gene Chr10:59304365-59338000 (-)
FVB/NJ MGP_FVBNJ_G0017132
 protein coding gene Chr10:58574972-58609625 (-)
LP/J MGP_LPJ_G0017212
 protein coding gene Chr10:62312953-62348815 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017160
 protein coding gene Chr10:68774998-68811793 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017734
 protein coding gene Chr10:61433983-61468676 (-)
PWK/PhJ MGP_PWKPhJ_G0016415
 protein coding gene Chr10:59172027-59208677 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016197
 protein coding gene Chr10:60807627-60841402 (-)
WSB/EiJ MGP_WSBEiJ_G0016696
 protein coding gene Chr10:61371328-61406411 (-)



Homology
more
  • Human Ortholog
    SRGN, serglycin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRGN, serglycin
  • Synonyms
    PPG, PRG, PRG1
  • Links
    NCBI Gene ID: 5552
    neXtProt AC: NX_P10124
    UniProt: P10124

  • Chr Location
    10q22.1; chr10:69087603-69104811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Srgn
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    17 strains or lines available
Mice homozygous for disruptions in this gene lack peritoneal mast cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    23
  • cDNA Data
    104
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19073 NCBI Gene Model | MGI Sequence Detail 33613 C57BL/6J ±  kb
transcript NM_001428755 RefSeq | MGI Sequence Detail 1257 C57BL/6  
polypeptide P13609 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 114
    Genomic 6
    cDNA 104
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13606, MGD-MRK-14384
References
more
  • Summaries
    All 71
    Developmental Gene Expression 7
    Gene Ontology 12
    Phenotypes 28
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:351156 Chen F, et al., Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration. Nat Commun. 2024 Jan 2;15(1):47
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory