Prl MGI Mouse Gene Detail - MGI:97762

Symbol

Prl
Name

prolactin
Synonyms

Prl1a1

Feature Type

protein coding gene
IDs

MGI:97762
NCBI Gene: 19109
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr13:27241553-27249187 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 12.25 cM
Mapping Data

13 experiments

SNPs within 2kb

328 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97762	protein coding gene	Chr13:27241553-27249188 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020390	protein coding gene	Chr13:24655189-24663564 (+)
A/J	MGP_AJ_G0020339	protein coding gene	Chr13:24133519-24140935 (+)
AKR/J	MGP_AKRJ_G0020319	protein coding gene	Chr13:24425116-24432796 (+)
BALB/cJ	MGP_BALBcJ_G0020337	protein coding gene	Chr13:24113290-24120651 (+)
C3H/HeJ	MGP_C3HHeJ_G0020141	protein coding gene	Chr13:24496554-24504306 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020774	protein coding gene	Chr13:25506605-25514193 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018362	protein coding gene	Chr13:22755437-22763086 (+)
CAST/EiJ	MGP_CASTEiJ_G0019658	protein coding gene	Chr13:24225120-24232587 (+)
CBA/J	MGP_CBAJ_G0020095	protein coding gene	Chr13:26512854-26524339 (+)
DBA/2J	MGP_DBA2J_G0020221	protein coding gene	Chr13:23663513-23670899 (+)
FVB/NJ	MGP_FVBNJ_G0020205	protein coding gene	Chr13:23261955-23269541 (+)
LP/J	MGP_LPJ_G0020294	protein coding gene	Chr13:24905750-24913144 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020232	protein coding gene	Chr13:26835878-26846539 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020816	protein coding gene	Chr13:24299471-24307322 (+)
PWK/PhJ	MGP_PWKPhJ_G0019412	protein coding gene	Chr13:23624387-23632223 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019228	protein coding gene	Chr13:23179933-23187722 (+)
WSB/EiJ	MGP_WSBEiJ_G0019718	protein coding gene	Chr13:24471506-24480573 (+)

Human Ortholog

PRL, prolactin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRL, prolactin
Synonyms

GHA1
Links

HGNC:9445

NCBI Gene ID: 5617

neXtProt AC: NX_P01236

UniProt: P01236
Chr Location

6p22.3; chr6:22287244-22302835 (-) GRCh38

MGI Vertebrate Homology

Prl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRL
Gene Tree

Prl

Diseases

2 with human PRL associations

				Human Disease	Mouse Models
				carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273
				impulse control disorder IDs impulse control disorder DOID:10937 ICD10CM:F63.9 ICD9CM:312.30 MESH:D007174 NCI:C34723 UMLS_CUI:C0021122

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

33 phenotypes from 1 allele in 1 genetic background
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Prl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null female mice have irregular oestrus cycles and are infertile. Defects of the pituitary gland include hyperplasia, which progresses to adenoma, and impaired secretion.

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All GO Annotations

35
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

29
cDNA Data

1364
Literature Summary

81

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PRL

Xenbase prl

ZFIN prl

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All Sequences

58
RefSeq

4
UniProt

6
CCDS

CCDS26389.1

Ensembl

ENSMUSG00000021342 (Evidence)
NCBI Gene

19109

			Length	Strain/Species	Flank
genomic	19109	NCBI Gene Model \| MGI Sequence Detail	7635	C57BL/6J	± kb
transcript	NM_011164	RefSeq \| MGI Sequence Detail	895	ZRU/MplStud
polypeptide	P06879	UniProt \| EBI \| MGI Sequence Detail	226	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013246 prolactin

(term hierarchy)
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR018116 Somatotropin hormone, conserved site

IPR001400 Somatotropin/prolactin

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All nucleic 1371

Genomic 1

cDNA 1364

Primer pair 5

Other 1

Microarray probesets 3

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MGD-MRK-13613, MGI:2145398

Summaries

All 229

Developmental Gene Expression 81

Gene Ontology 14

Phenotypes 43
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)

TSS for Prl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119013	Chr13:27241554-27241567 (+)	8 bp
Tssr119014	Chr13:27241584-27241594 (+)	36 bp
Tssr119015	Chr13:27243365-27243374 (+)	1,817 bp
Tssr119016	Chr13:27243415-27243422 (+)	1,866 bp
Tssr119017	Chr13:27243481-27243490 (+)	1,933 bp
Tssr119018	Chr13:27245510-27245521 (+)	3,963 bp
Tssr119019	Chr13:27248327-27248339 (+)	6,780 bp
Tssr119020	Chr13:27249125-27249131 (+)	7,575 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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