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Prlr Gene Detail
Summary
  • Symbol
    Prlr
  • Name
    prolactin receptor
  • Synonyms
    Pr-1, Prlr-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97763
    NCBI Gene: 19116
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:10177324-10349266 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.23 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4364 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97763
 protein coding gene Chr15:10177324-10349276 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021718
 protein coding gene Chr15:7292566-7474729 (+)
A/J MGP_AJ_G0021678
 protein coding gene Chr15:7121867-7292749 (+)
AKR/J MGP_AKRJ_G0021656
 protein coding gene Chr15:7279762-7453704 (+)
BALB/cJ MGP_BALBcJ_G0021685
 protein coding gene Chr15:7024654-7200386 (+)
C3H/HeJ MGP_C3HHeJ_G0021461
 protein coding gene Chr15:7217428-7398751 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022124
 protein coding gene Chr15:7574335-7764721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019661
 protein coding gene Chr15:6595629-6767842 (+)
CAST/EiJ MGP_CASTEiJ_G0020977
 protein coding gene Chr15:7273799-7462136 (+)
CBA/J MGP_CBAJ_G0021430
 protein coding gene Chr15:7728367-7919328 (+)
DBA/2J MGP_DBA2J_G0021554
 protein coding gene Chr15:6977449-7150032 (+)
FVB/NJ MGP_FVBNJ_G0021532
 protein coding gene Chr15:6844830-7016809 (+)
LP/J MGP_LPJ_G0021622
 protein coding gene Chr15:7200454-7378965 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021557
 protein coding gene Chr15:8045978-8232241 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022147
 protein coding gene Chr15:7244453-7414681 (+)
PWK/PhJ MGP_PWKPhJ_G0020720
 protein coding gene Chr15:7133641-7315719 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020558
 protein coding gene Chr15:7191910-7380379 (+)
WSB/EiJ MGP_WSBEiJ_G0021033
 protein coding gene Chr15:7247779-7428930 (+)



Homology
more
  • Human Ortholog
    PRLR, prolactin receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRLR, prolactin receptor
  • Synonyms
    HPRL, hPRLrI, MFAB, RI-PRLR
  • Links
    NCBI Gene ID: 5618
    neXtProt AC: NX_P16471
    UniProt: P16471

  • Chr Location
    5p13.2; chr5:35048756-35230487 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prlr mouse models; 1 with human PRLR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 2 alleles in 8 genetic backgrounds
    18 phenotypes from multigenic genotypes
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal growth, hormone and glucose homeostasis, hair cycling, female reproductive behavior, morphology, and function, and thyroid, prostate, Hardarian, and lacrimal gland morphologies. Heterozygous mice exhibit defective neuron proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1013
  • Tissues
    117
  • cDNA Data
    38
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005268 Ensembl Gene Model | MGI Sequence Detail 171943 C57BL/6J ±  kb
    transcript ENSMUST00000124470 Ensembl | MGI Sequence Detail 9900 Not Applicable  
    polypeptide ENSMUSP00000122219 Ensembl | MGI Sequence Detail 608 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 1
      cDNA 42
      Primer pair 14
      Other 2

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-13598, MGD-MRK-13599, MGD-MRK-13614, MGD-MRK-13615, MGI:2146103, MGI:97764
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 16
      Phenotypes 95
    • Earliest
      J:7060 Herington AC, et al., Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology. 1983 Jun;112(6):2032-8
    • Latest
      J:349473 Vazquez-Carrillo DI, et al., Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice. PLoS One. 2024;19(4):e0301496
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory