Prm1 MGI Mouse Gene Detail - MGI:97765

Symbol

Prm1
Name

protamine 1
Synonyms

Prm-1

Feature Type

protein coding gene
IDs

MGI:97765
NCBI Gene: 19118
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:10614196-10614687 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 5.87 cM, cytoband cen-C3
Mapping Data

63 experiments

SNPs within 2kb

90 from dbSNP Build 142
Strain Annotations

18
RFLP

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97765	protein coding gene	Chr16:10614190-10623703 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022515	protein coding gene	Chr16:7623689-7624249 (-)
A/J	MGP_AJ_G0022477	protein coding gene	Chr16:7206123-7206683 (-)
AKR/J	MGP_AKRJ_G0022453	protein coding gene	Chr16:7526274-7526834 (-)
BALB/cJ	MGP_BALBcJ_G0022481	protein coding gene	Chr16:7336782-7337342 (-)
C3H/HeJ	MGP_C3HHeJ_G0022248	protein coding gene	Chr16:7611606-7612166 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022930	protein coding gene	Chr16:7771118-7771678 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020451	protein coding gene	Chr16:7352878-7353433 (-)
CAST/EiJ	MGP_CASTEiJ_G0021775	protein coding gene	Chr16:7630724-7631284 (-)
CBA/J	MGP_CBAJ_G0022217	protein coding gene	Chr16:8122986-8123546 (-)
DBA/2J	MGP_DBA2J_G0022348	protein coding gene	Chr16:7209438-7209998 (-)
FVB/NJ	MGP_FVBNJ_G0022324	protein coding gene	Chr16:7191674-7192234 (-)
LP/J	MGP_LPJ_G0022416	protein coding gene	Chr16:7576003-7576563 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022346	protein coding gene	Chr16:7831122-7831682 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022943	protein coding gene	Chr16:7481788-7482348 (-)
PWK/PhJ	MGP_PWKPhJ_G0021515	protein coding gene	Chr16:7418291-7418851 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021345	protein coding gene	Chr16:7540373-7540933 (-)
WSB/EiJ	MGP_WSBEiJ_G0021823	protein coding gene	Chr16:7560412-7560972 (-)

Human Ortholog

PRM1, protamine 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRM1, protamine 1
Synonyms

CT94.1, P1
Links

HGNC:9447

NCBI Gene ID: 5619

neXtProt AC: NX_P04553

UniProt: P04553
Chr Location

16p13.13; chr16:11280841-11281330 (-) GRCh38

MGI Vertebrate Homology

Prm1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRM1
Gene Tree

Prm1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

In chimeras deformed sperm with loosely compacted chromatin are derived from spermatogenic cells with one copy of the mutated allele. No offspring carrying the mutated allele are produced from matings using chimeras.

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All GO Annotations

13
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

6
cDNA Data

229
Literature Summary

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS27956.1

Ensembl

ENSMUSG00000022501 (Evidence)
NCBI Gene

19118

			Length	Strain/Species	Flank
genomic	19118	NCBI Gene Model \| MGI Sequence Detail	492	C57BL/6J	± kb
transcript	NM_013637	RefSeq \| MGI Sequence Detail	400	ZRU/MplStud
polypeptide	P02319	UniProt \| EBI \| MGI Sequence Detail	51	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013249 sperm protamine P1

(term hierarchy)
InterPro Domains

IPR000221 Protamine P1

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All nucleic 238

Genomic 3

cDNA 230

Primer pair 3

Other 2

Microarray probesets 5

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MGD-MRK-13616, MGD-MRK-13618

Summaries

All 122

Developmental Gene Expression 19

Gene Ontology 10

Phenotypes 4
Earliest

J:7131 Kleene KC, et al., cDNA clones encoding cytoplasmic poly(A)+ RNAs which first appear at detectable levels in haploid phases of spermatogenesis in the mouse. Dev Biol. 1983 Aug;98(2):455-64
Latest

J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)

TSS for Prm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139966	Chr16:10614679-10614694 (-)	0 bp
Tssr139965	Chr16:10614395-10614403 (-)	288 bp
Tssr139964	Chr16:10614375-10614388 (-)	305 bp
Tssr139963	Chr16:10614275-10614278 (-)	410 bp
Tssr139962	Chr16:10614231-10614238 (-)	452 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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