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Prn Gene Detail
Summary
  • Symbol
    Prn
  • Name
    prion protein readthrough transcript
  • Synonyms
    Gm28045, Gm44637
  • Feature Type
    protein coding gene
  • IDs
    MGI:97767
    NCBI Gene: 111368
  • Cluster Members
    Prnp, Prnd (2 members)
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131751877-131798050 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, Syntenic
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97767
 protein coding gene Chr2:131751848-131798051 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026535
 protein coding gene Chr2:135470006-135511264 (+)
A/J MGP_AJ_G0026499
 protein coding gene Chr2:129962259-129996944 (+)
AKR/J MGP_AKRJ_G0026474
 protein coding gene Chr2:133697763-133733925 (+)
BALB/cJ MGP_BALBcJ_G0026511
 protein coding gene Chr2:130355753-130389597 (+)
C3H/HeJ MGP_C3HHeJ_G0026254
 protein coding gene Chr2:134165224-134201183 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026956
 protein coding gene Chr2:139605162-139642487 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024333
 protein coding gene Chr2:124695809-124728770 (+)
CAST/EiJ MGP_CASTEiJ_G0025715
 protein coding gene Chr2:134476022-134512182 (+)
CBA/J MGP_CBAJ_G0026234
 protein coding gene Chr2:144835585-144871498 (+)
DBA/2J MGP_DBA2J_G0026368
 protein coding gene Chr2:129359360-129393489 (+)
FVB/NJ MGP_FVBNJ_G0026332
 protein coding gene Chr2:127980282-128014233 (+)
LP/J MGP_LPJ_G0026473
 protein coding gene Chr2:135683614-135719627 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026352
 protein coding gene Chr2:148632553-148667294 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027011
 protein coding gene Chr2:133681024-133719335 (+)
PWK/PhJ MGP_PWKPhJ_G0025451
 protein coding gene Chr2:128941944-128976939 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025253
 protein coding gene Chr2:132829823-132870010 (+)
WSB/EiJ MGP_WSBEiJ_G0025789
 protein coding gene Chr2:134601473-134639589 (+)



Homology
more
  • Human Ortholog
    PRND, prion like protein doppel
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRND, prion like protein doppel
  • Synonyms
    dJ1068H6.4, DOPPEL, DPL, PrPLP
  • Links
    NCBI Gene ID: 23627
    neXtProt AC: NX_Q9UKY0
    UniProt: Q9UKY0

  • Chr Location
    20p13; chr20:4721909-4728460 (+)  GRCh38
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000098754 Ensembl Gene Model | MGI Sequence Detail 46174 C57BL/6J ±  kb
transcript ENSMUST00000136783 Ensembl | MGI Sequence Detail 3370 Not Applicable  
polypeptide ENSMUSP00000122345 Ensembl | MGI Sequence Detail 197 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR036924 Prion/Doppel beta-ribbon domain superfamily
    IPR022416 Prion/Doppel protein, beta-ribbon domain
    IPR021566 Prion-like protein Doppel
Molecular
Reagents
less
  • All nucleic 1
    Genomic 1
Other
Accession IDs
less
MGD-MRK-13620, MGI:5547781, MGI:5753213
References
more
  • Summaries
    All 38
    Gene Ontology 1
  • Earliest
    J:8350 Carlson GA, et al., Linkage of prion protein and scrapie incubation time genes. Cell. 1986 Aug 15;46(4):503-11
  • Latest
    J:237304 Slapsak U, et al., The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain. J Biol Chem. 2016 Oct 14;291(42):21857-21868
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory