Proc MGI Mouse Gene Detail - MGI:97771

Symbol

Proc
Name

protein C
Synonyms

inactivator of coagulation factors Va, VIII, PC

Feature Type

protein coding gene
IDs

MGI:97771
NCBI Gene: 19123
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:32256179-32272623 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 17.94 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

505 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97771	protein coding gene	Chr18:32256179-32272623 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024224	protein coding gene	Chr18:30247716-30267275 (-)
A/J	MGP_AJ_G0024190	protein coding gene	Chr18:29242357-29260001 (-)
AKR/J	MGP_AKRJ_G0024159	protein coding gene	Chr18:30058606-30077040 (-)
BALB/cJ	MGP_BALBcJ_G0024190	protein coding gene	Chr18:29339101-29355937 (-)
C3H/HeJ	MGP_C3HHeJ_G0023958	protein coding gene	Chr18:30092611-30115475 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024632	protein coding gene	Chr18:31332164-31350929 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022073	protein coding gene	Chr18:29479226-29494929 (-)
CAST/EiJ	MGP_CASTEiJ_G0023433	protein coding gene	Chr18:29993049-30008453 (-)
CBA/J	MGP_CBAJ_G0023926	protein coding gene	Chr18:32283836-32306543 (-)
DBA/2J	MGP_DBA2J_G0024058	protein coding gene	Chr18:28916598-28933156 (-)
FVB/NJ	MGP_FVBNJ_G0024024	protein coding gene	Chr18:28622977-28641453 (-)
LP/J	MGP_LPJ_G0024139	protein coding gene	Chr18:30336012-30353443 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024052	protein coding gene	Chr18:33629110-33647052 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024680	protein coding gene	Chr18:29914647-29933395 (-)
PWK/PhJ	MGP_PWKPhJ_G0023176	protein coding gene	Chr18:29083129-29099949 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022985	protein coding gene	Chr18:30158208-30176964 (-)
WSB/EiJ	MGP_WSBEiJ_G0023496	protein coding gene	Chr18:29821788-29841516 (-)

Human Ortholog

PROC, protein C, inactivator of coagulation factors Va and VIIIa

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PROC, protein C, inactivator of coagulation factors Va and VIIIa
Synonyms

APC, PC, PROC1, THPH3, THPH4
Links

HGNC:9451

NCBI Gene ID: 5624

neXtProt AC: NX_P04070

UniProt: P04070
Chr Location

2q14.3; chr2:127418427-127429242 (+) GRCh38

MGI Vertebrate Homology

Proc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PROC
Protein SuperFamily

Factor_X
Gene Tree

Proc

Diseases

13 with human PROC associations

				Human Disease	Mouse Models
				acute kidney failure IDs acute kidney failure DOID:3021 MESH:D058186
				antiphospholipid syndrome IDs antiphospholipid syndrome DOID:2988 ICD10CM:D68.61 MESH:D016736 NCI:C61283 OMIM:107320 UMLS_CUI:C0085278
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				autosomal dominant thrombophilia due to protein C deficiency IDs autosomal dominant thrombophilia due to protein C deficiency DOID:0111909 MESH:C567163 OMIM:176860 UMLS_CUI:C2674321
				autosomal recessive thrombophilia due to protein C deficiency IDs autosomal recessive thrombophilia due to protein C deficiency DOID:0111904 MESH:C567353 OMIM:612304 UMLS_CUI:C2676759
				central retinal vein occlusion IDs central retinal vein occlusion DOID:2450 ICD10CM:H34.81 ICD9CM:362.35 MESH:D012170 NCI:C118859 UMLS_CUI:C0154841
				placental abruption IDs placental abruption DOID:9667 DOID:12976 DOID:12977 DOID:13233 DOID:13234 DOID:13587 DOID:13627 DOID:14406 DOID:9666 ICD10CM:O20.0 ICD9CM:640.0 ICD9CM:640.03 MESH:D000033 NCI:C112857 UMLS_CUI:C0000821
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914
				protein C deficiency IDs protein C deficiency DOID:3756 ICD10CM:D68.59 MESH:D020151 NCI:C99025 ORDO:745 UMLS_CUI:C0398625
				thrombophilia IDs thrombophilia DOID:2452 ICD10CM:D68.59 MESH:D019851 NCI:C84479 OMIM:PS188050 UMLS_CUI:C0398623
				thrombophilia due to activated protein C resistance IDs thrombophilia due to activated protein C resistance DOID:0111902 MESH:C566056 OMIM:188055 UMLS_CUI:C1861171
				thrombosis IDs thrombosis DOID:0060903 MESH:D013927
				toxic shock syndrome IDs toxic shock syndrome DOID:14115 ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 UMLS_CUI:C0600327

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
43 phenotypes from multigenic genotypes
2 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

1
Targeted

3
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of the locus results in death within 24 hours of birth due to consumptive coagulopathy. Thromboses and bleeding are observed in the brains and livers of homozygous mutant mice.

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

13
cDNA Data

22
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase proc, proc.2

ZFIN proca

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All Sequences

75
RefSeq

16
UniProt

5
CCDS

CCDS29116.1

Ensembl

ENSMUSG00000024386 (Evidence)
NCBI Gene

19123

			Length	Strain/Species	Flank
genomic	19123	NCBI Gene Model \| MGI Sequence Detail	16445	C57BL/6J	± kb
transcript	NM_001042768	RefSeq \| MGI Sequence Detail	1652	C57BL/6
polypeptide	P33587	UniProt \| EBI \| MGI Sequence Detail	460	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013261 vitamin K-dependent protein C

(term hierarchy)
EC

3.4.21.69
InterPro Domains

IPR017857 Coagulation factor-like, Gla domain superfamily

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain

IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR001314 Peptidase S1A, chymotrypsin family

IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

IPR050442 Peptidase S1 family, coagulation factors

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site
GlyGen

P33587 3 sites, 1 N-linked glycan (1 site)

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All nucleic 25

Genomic 1

cDNA 23

Primer pair 1

Microarray probesets 5

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MGD-MRK-13625

Summaries

All 74

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 18
Earliest

J:1257 Tada N, et al., Isolation and characterization of a mouse protein C cDNA. J Biochem. 1992 Apr;111(4):491-5
Latest

J:322319 Xue M, et al., Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2. Int J Mol Sci. 2022 Jan 3;23(1)

TSS for Proc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152733	Chr18:32271228-32271252 (-)	1,383 bp
Tssr152732	Chr18:32271215-32271222 (-)	1,404 bp
Tssr152731	Chr18:32271073-32271080 (-)	1,546 bp
Tssr152730	Chr18:32269564-32269567 (-)	3,057 bp
Tssr152729	Chr18:32269005-32269007 (-)	3,617 bp
Tssr152728	Chr18:32267712-32267743 (-)	4,895 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24