Prt3 Gene Detail

Summary

• Symbol
  Prt3
• Name
  pancreatic proteinase 3
• Synonyms
  Prt-3

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:97778
  NCBI Gene: 104300
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

This locus controls activity of trypsin I and trypsinogen I. The b allele determines high activity in MOL-A; the a allele determines low activity in other strains tested. The difference is in specific activity of enzymes determined by the two alleles. Heterozygotes are intermediate.

Sequences &
Gene Models

• NCBI Gene
  104300

Other
Accession IDs

MGD-MRK-13635, MGD-MRK-13640

References

• Summaries
  All 7
• Earliest
  J:5753 Watanabe T, et al., Genetic study of pancreatic proteinase in mice (Mus musculus): genetic variants of trypsin and chymotrypsin. Biochem Genet. 1976 Oct;14(9-10):697-707
• Latest
  J:310680 Karatepe K, et al., Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow. Stem Cell Reports. 2018 Nov 13;11(5):1092-1105