Ptgs2 Gene Detail

Summary

• Symbol
  Ptgs2
• Name
  prostaglandin-endoperoxide synthase 2
• Synonyms
  Cox-2, COX2, cyclooxygenase 2, cyclooxygenase-2, Pghs2, PGHS-2, PHS-2, prostaglandin G/H synthase, Tis10

• Feature Type
  protein coding gene
• IDs
  MGI:97798
  NCBI Gene: 19225
• Alliance
  gene page
• Transcription Start Sites
  98 TSS

Location &
Maps

• Sequence Map
  Chr1:149975851-149983978 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 63.84 cM, cytoband H1
• Mapping Data
  8 experiments

Strain
Comparison

• SNPs within 2kb
  251 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97798	protein coding gene	Chr1:149975782-149983978 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016572	protein coding gene	Chr1:154740570-154750088 (+)
A/J	MGP_AJ_G0016555	protein coding gene	Chr1:148484211-148492398 (+)
AKR/J	MGP_AKRJ_G0016520	protein coding gene	Chr1:153014363-153022561 (+)
BALB/cJ	MGP_BALBcJ_G0016515	protein coding gene	Chr1:149038524-149044490 (+)
C3H/HeJ	MGP_C3HHeJ_G0016340	protein coding gene	Chr1:153215875-153224249 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016976	protein coding gene	Chr1:160079479-160089284 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014685	protein coding gene	Chr1:140811873-140819953 (+)
CAST/EiJ	MGP_CASTEiJ_G0015919	protein coding gene	Chr1:152643515-152652768 (+)
CBA/J	MGP_CBAJ_G0016314	protein coding gene	Chr1:165765095-165773175 (+)
DBA/2J	MGP_DBA2J_G0016420	protein coding gene	Chr1:147545652-147554380 (+)
FVB/NJ	MGP_FVBNJ_G0016418	protein coding gene	Chr1:145985788-145994129 (+)
LP/J	MGP_LPJ_G0016491	protein coding gene	Chr1:155742553-155750692 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016444	protein coding gene	Chr1:173453468-173462398 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017012	protein coding gene	Chr1:152838040-152846222 (+)
PWK/PhJ	MGP_PWKPhJ_G0015705	protein coding gene	Chr1:146477487-146486875 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015492	protein coding gene	Chr1:151538752-151556977 (+)
WSB/EiJ	MGP_WSBEiJ_G0015982	protein coding gene	Chr1:152938844-152947301 (+)

Homology

• Human Ortholog
  PTGS2, prostaglandin-endoperoxide synthase 2

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PTGS2, prostaglandin-endoperoxide synthase 2
  
• Synonyms
  COX-2, COX2, GRIPGHS, hCox-2, PGG/HS, PGHS-2, PHS-2
• Links
  HGNC:9605

  NCBI Gene ID: 5743

  neXtProt AC: NX_P35354

  UniProt: P35354

  
  
• Chr Location
  1q31.1; chr1:186671791-186680922 (-)  GRCh38

---

• MGI Vertebrate Homology
  Ptgs2 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: PTGS2
• Gene Tree
  Ptgs2
  

Human Diseases

• Diseases
  19 with human PTGS2 associations

				Human Disease	Mouse Models
				arteriosclerosis IDs arteriosclerosis       DOID:2349 ICD10CM:I70 MESH:D001161 NCI:C34398 UMLS_CUI:C0003850
				asthma IDs asthma       DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				avian influenza IDs avian influenza       DOID:4492 ICD10CM:J09.X MESH:D005585 UMLS_CUI:C0016627
				cardiovascular system disease IDs cardiovascular system disease       DOID:1287 DOID:73 ICD9CM:429.2 MESH:D002318 NCI:C2931 UMLS_CUI:C0007222
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease       DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				cystic fibrosis IDs cystic fibrosis       DOID:1485 DOID:12447 DOID:13383 DOID:14395 DOID:1484 ICD10CM:E84 ICD9CM:277.0 MESH:D003550 NCI:C2975 OMIM:219700 ORDO:586 UMLS_CUI:C0010674
				esophagitis IDs esophagitis       DOID:11963 DOID:11962 ICD10CM:K20 ICD9CM:530.1 ICD9CM:530.10 MESH:D004941 NCI:C9224 UMLS_CUI:C0014868
				hepatocellular carcinoma IDs hepatocellular carcinoma       DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				idiopathic pulmonary fibrosis IDs idiopathic pulmonary fibrosis       DOID:0050156 EFO:0000768 ICD10CM:J84.112 ICD9CM:516.31 MESH:D054990 NCI:C35716 UMLS_CUI:C1800706
				liver cirrhosis IDs liver cirrhosis       DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890
				lung non-small cell carcinoma IDs lung non-small cell carcinoma       DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				myocardial infarction IDs myocardial infarction       DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				osteoarthritis IDs osteoarthritis       DOID:8398 ICD9CM:715.3 UMLS_CUI:C0157946
				pancreatic cancer IDs pancreatic cancer       DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463
				prostate cancer IDs prostate cancer       DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				pulmonary fibrosis IDs pulmonary fibrosis       DOID:3770 MESH:D011658 NCI:C26869 UMLS_CUI:C0034069
				rheumatoid arthritis IDs rheumatoid arthritis       DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873
				sarcoidosis IDs sarcoidosis       DOID:11335 ICD10CM:D86 ICD9CM:135 MESH:D012507 NCI:C34995 ORDO:797 UMLS_CUI:C0036202
				urinary bladder cancer IDs urinary bladder cancer       DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  202 phenotypes from 14 alleles in 23 genetic backgrounds
  36 phenotypes from multigenic genotypes
  3 images
  349 phenotype references
  

• All Mutations and Alleles
  37
• Chemically induced (other)
  2
• Endonuclease-mediated
  8
• Targeted
  21
• Transgenic
  6
• Genomic Mutations
  3 involving Ptgs2
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  73 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous null mice exhibit increased perinatal mortality associated with frequent lack of closure and remodeling of the ductus arteriosus, background-sensitive kidney dysplasia with microcyst formation, and myocardial fibrosis. Mutant females show impaired fertility.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  130
• GO References
  31

Expression

• Assay Results
  964
• Tissues
  164
• cDNA Data
  25
• Literature Summary
  66

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase ptgs2
  ZFIN ptgs2a, ptgs2b

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  2
• UniProt
  4
• CCDS
  CCDS15353.1

• Ensembl
  ENSMUSG00000032487 (Evidence)
• NCBI Gene
  19225

Representative Sequences			Length	Strain/Species
genomic	19225	NCBI Gene Model | MGI Sequence Detail	8128	C57BL/6J
transcript	NM_011198	RefSeq | MGI Sequence Detail	4384	ZRU/MplStud
polypeptide	Q05769	UniProt | EBI | MGI Sequence Detail	604	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000013428 prostaglandin G/H synthase 2
  (term hierarchy)
• PDB
  1CVU, 1CX2, 1DDX, 1PXX, 3HS5, 3HS6, 3HS7, 3KRK, 3LN0, 3LN1, 3MDL, 3MQE, 3NT1, 3NTB, 3NTG, 3OLT, 3OLU, 3PGH, 3Q7D, 3QH0, 3QMO, 3RR3, 3TZI, 4COX, 4E1G, 4FM5, 4M10, 4M11, 4OTJ, 4OTY, 4PH9, 4RRW, 4RRX, 4RRY, 4RRZ, 4RS0, 4RUT, 4Z0L, 5COX, 5FDQ, 5JVY, 5JVZ, 5JW1, 5W58, 6BL3, 6BL4, 6COX, 6OFY, 6V3R, 8ET0
• EC
  1.14.99.1
• InterPro Domains
  IPR000742 EGF-like domain
  IPR019791 Haem peroxidase, animal-type
  IPR037120 Haem peroxidase domain superfamily, animal type
  IPR010255 Haem peroxidase superfamily
  IPR050783 Oxylipin biosynthesis and metabolism
• GlyGen
  Q05769 4 sites, 14 N-linked glycans (4 sites)

Molecular
Reagents

• All nucleic 43

  Genomic 6

  cDNA 26

  Primer pair 9

  Other 2

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-13665

References

• Summaries
  All 661

  Developmental Gene Expression 66

  Diseases 1

  Gene Ontology 31

  Phenotypes 349
• Earliest
  J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
• Latest
  J:358231 Jiang Z, et al., Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2024;17(3):321-346

TSS for Ptgs2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9221	Chr1:149975487-149975508 (+)	-353 bp
Tssr9222	Chr1:149975844-149975857 (+)	0 bp
Tssr9223	Chr1:149976697-149976700 (+)	848 bp
Tssr9224	Chr1:149976715-149976808 (+)	911 bp
Tssr9225	Chr1:149976922-149976933 (+)	1,077 bp
Tssr9226	Chr1:149976935-149976946 (+)	1,090 bp
Tssr9227	Chr1:149976955-149977024 (+)	1,139 bp
Tssr9228	Chr1:149977046-149977064 (+)	1,204 bp
Tssr9229	Chr1:149977068-149977077 (+)	1,222 bp
Tssr9230	Chr1:149977728-149977864 (+)	1,945 bp
Tssr9231	Chr1:149977880-149977897 (+)	2,038 bp
Tssr9232	Chr1:149977920-149977940 (+)	2,079 bp
Tssr9233	Chr1:149978393-149978396 (+)	2,544 bp
Tssr9234	Chr1:149978397-149978425 (+)	2,560 bp
Tssr9235	Chr1:149978437-149978456 (+)	2,596 bp
Tssr9236	Chr1:149978474-149978481 (+)	2,627 bp
Tssr9237	Chr1:149978493-149978513 (+)	2,652 bp
Tssr9238	Chr1:149978522-149978544 (+)	2,682 bp
Tssr242	Chr1:149978551-149978556 (+)	2,703 bp
Tssr9239	Chr1:149978563-149978578 (+)	2,720 bp
Tssr9240	Chr1:149978585-149978592 (+)	2,738 bp
Tssr9241	Chr1:149978611-149978622 (+)	2,766 bp
Tssr9242	Chr1:149978631-149978638 (+)	2,784 bp
Tssr9243	Chr1:149978755-149978765 (+)	2,909 bp
Tssr9244	Chr1:149978800-149978816 (+)	2,957 bp
Tssr9245	Chr1:149978820-149978852 (+)	2,985 bp
Tssr9246	Chr1:149978857-149978871 (+)	3,013 bp
Tssr9247	Chr1:149978996-149979006 (+)	3,150 bp
Tssr9248	Chr1:149979416-149979439 (+)	3,577 bp
Tssr9249	Chr1:149979443-149979453 (+)	3,597 bp
Tssr9250	Chr1:149979611-149979654 (+)	3,782 bp
Tssr9251	Chr1:149979657-149979706 (+)	3,831 bp
Tssr9252	Chr1:149979712-149979741 (+)	3,876 bp
Tssr9253	Chr1:149979742-149979766 (+)	3,903 bp
Tssr9254	Chr1:149979769-149979782 (+)	3,925 bp
Tssr9255	Chr1:149979788-149979833 (+)	3,960 bp
Tssr9256	Chr1:149980028-149980038 (+)	4,182 bp
Tssr9257	Chr1:149980052-149980072 (+)	4,211 bp
Tssr9258	Chr1:149980075-149980088 (+)	4,231 bp
Tssr9259	Chr1:149980100-149980145 (+)	4,272 bp
Tssr9260	Chr1:149980155-149980197 (+)	4,325 bp
Tssr9261	Chr1:149980210-149980216 (+)	4,362 bp
Tssr9262	Chr1:149980218-149980237 (+)	4,377 bp
Tssr9263	Chr1:149980240-149980249 (+)	4,394 bp
Tssr9264	Chr1:149980285-149980298 (+)	4,441 bp
Tssr9265	Chr1:149980316-149980325 (+)	4,470 bp
Tssr9266	Chr1:149980405-149980414 (+)	4,559 bp
Tssr9267	Chr1:149980696-149980749 (+)	4,872 bp
Tssr9268	Chr1:149980752-149980819 (+)	4,935 bp
Tssr9269	Chr1:149981135-149981156 (+)	5,295 bp
Tssr9270	Chr1:149981175-149981187 (+)	5,330 bp
Tssr9271	Chr1:149981199-149981210 (+)	5,354 bp
Tssr9272	Chr1:149981229-149981241 (+)	5,384 bp
Tssr9273	Chr1:149981281-149981285 (+)	5,432 bp
Tssr9274	Chr1:149981299-149981305 (+)	5,451 bp
Tssr9275	Chr1:149981326-149981337 (+)	5,481 bp
Tssr9276	Chr1:149981341-149981351 (+)	5,495 bp
Tssr9277	Chr1:149981391-149981407 (+)	5,548 bp
Tssr9278	Chr1:149981412-149981428 (+)	5,569 bp
Tssr9279	Chr1:149981433-149981446 (+)	5,589 bp
Tssr9280	Chr1:149981450-149981546 (+)	5,647 bp
Tssr9281	Chr1:149981556-149981566 (+)	5,710 bp
Tssr9282	Chr1:149981591-149981600 (+)	5,745 bp
Tssr9283	Chr1:149981605-149981615 (+)	5,759 bp
Tssr9284	Chr1:149981620-149981627 (+)	5,773 bp
Tssr9285	Chr1:149981630-149981641 (+)	5,785 bp
Tssr9286	Chr1:149981714-149981720 (+)	5,866 bp
Tssr9287	Chr1:149982227-149982236 (+)	6,381 bp
Tssr9288	Chr1:149982343-149982350 (+)	6,496 bp
Tssr9289	Chr1:149982360-149982367 (+)	6,513 bp
Tssr9290	Chr1:149982516-149982521 (+)	6,668 bp
Tssr9291	Chr1:149982562-149982569 (+)	6,715 bp
Tssr9292	Chr1:149982681-149982697 (+)	6,838 bp
Tssr9293	Chr1:149982710-149982713 (+)	6,861 bp
Tssr9294	Chr1:149982730-149982736 (+)	6,882 bp
Tssr9295	Chr1:149982746-149982763 (+)	6,904 bp
Tssr9296	Chr1:149982768-149982775 (+)	6,921 bp
Tssr9297	Chr1:149982777-149982788 (+)	6,932 bp
Tssr9298	Chr1:149982803-149982814 (+)	6,958 bp
Tssr9299	Chr1:149982825-149982832 (+)	6,978 bp
Tssr9300	Chr1:149982842-149982851 (+)	6,996 bp
Tssr9301	Chr1:149982976-149982984 (+)	7,129 bp
Tssr9302	Chr1:149983006-149983008 (+)	7,156 bp
Tssr9303	Chr1:149983068-149983084 (+)	7,225 bp
Tssr9304	Chr1:149983092-149983104 (+)	7,247 bp
Tssr9305	Chr1:149983110-149983113 (+)	7,261 bp
Tssr9306	Chr1:149983122-149983125 (+)	7,273 bp
Tssr9307	Chr1:149983126-149983151 (+)	7,288 bp
Tssr9308	Chr1:149983159-149983168 (+)	7,313 bp
Tssr9309	Chr1:149983173-149983190 (+)	7,331 bp
Tssr9310	Chr1:149983204-149983215 (+)	7,359 bp
Tssr9311	Chr1:149983216-149983238 (+)	7,376 bp
Tssr9312	Chr1:149983241-149983256 (+)	7,398 bp
Tssr9313	Chr1:149983261-149983264 (+)	7,412 bp
Tssr9314	Chr1:149983272-149983283 (+)	7,427 bp
Tssr9315	Chr1:149983366-149983375 (+)	7,520 bp
Tssr9316	Chr1:149983549-149983560 (+)	7,704 bp
Tssr9317	Chr1:149983826-149983846 (+)	7,985 bp