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Ptpn2 Gene Detail
Summary
  • Symbol
    Ptpn2
  • Name
    protein tyrosine phosphatase, non-receptor type 2
  • Synonyms
    Ptpt, TC-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97806
    NCBI Gene: 19255
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:67798581-67857665 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 40.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1533 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97806
 protein coding gene Chr18:67798571-67857697 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024529
 protein coding gene Chr18:67972928-68042099 (-)
A/J MGP_AJ_G0024496
 protein coding gene Chr18:65006780-65069771 (-)
AKR/J MGP_AKRJ_G0024467
 protein coding gene Chr18:66912190-66984935 (-)
BALB/cJ MGP_BALBcJ_G0024496
 protein coding gene Chr18:65169607-65232126 (-)
C3H/HeJ MGP_C3HHeJ_G0024264
 protein coding gene Chr18:67064617-67127566 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024942
 protein coding gene Chr18:69759422-69826980 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022373
 protein coding gene Chr18:64373756-64435992 (-)
CAST/EiJ MGP_CASTEiJ_G0023736
 protein coding gene Chr18:67067584-67135238 (-)
CBA/J MGP_CBAJ_G0024233
 protein coding gene Chr18:72166629-72233273 (-)
DBA/2J MGP_DBA2J_G0024363
 protein coding gene Chr18:64654081-64714122 (-)
FVB/NJ MGP_FVBNJ_G0024329
 protein coding gene Chr18:64026515-64085753 (-)
LP/J MGP_LPJ_G0024447
 protein coding gene Chr18:67835468-67899858 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024359
 protein coding gene Chr18:73439761-73504341 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024990
 protein coding gene Chr18:67076037-67144270 (-)
PWK/PhJ MGP_PWKPhJ_G0023481
 protein coding gene Chr18:64939353-64999748 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023285
 protein coding gene Chr18:67244531-67302718 (-)
WSB/EiJ MGP_WSBEiJ_G0023800
 protein coding gene Chr18:66986995-67050251 (-)



Homology
more
  • Human Ortholog
    PTPN2, protein tyrosine phosphatase non-receptor type 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN2, protein tyrosine phosphatase non-receptor type 2
  • Synonyms
    PTN2, PTPT, TC45, TC48, TCELLPTP, TC-PTP, TCPTP
  • Links
    NCBI Gene ID: 5771
    neXtProt AC: NX_P17706
    UniProt: P17706

  • Chr Location
    18p11.21; chr18:12785478-12929643 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    96 phenotypes from 5 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    3 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a reduced life span, abnormalities of the hematopoietic system and an increased succeptibility to inflammatory disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    22
  • cDNA Data
    118
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024539 Ensembl Gene Model | MGI Sequence Detail 59085 C57BL/6J ±  kb
    transcript ENSMUST00000122412 Ensembl | MGI Sequence Detail 2667 Not Applicable  
    polypeptide ENSMUSP00000112675 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000013454 tyrosine-protein phosphatase non-receptor type 2
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR051985 Non-receptor type tyrosine-specific phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      Q06180 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 119
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-13675, MGD-MRK-13686, MGI:2147211
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 4
      Gene Ontology 21
      Phenotypes 61
    • Earliest
      J:1925 Mosinger B Jr, et al., Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):499-503
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory