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Ptpra Gene Detail
Summary
  • Symbol
    Ptpra
  • Name
    protein tyrosine phosphatase receptor type A
  • Synonyms
    Ptpa, PTP[a], PTPalpha, RPTPalpha, RPTRalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:97808
    NCBI Gene: 19262
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130292198-130396220 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.23 cM, cytoband G
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2434 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97808
protein coding gene Chr2:130292198-130398044 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026506
protein coding gene Chr2:133909868-134017027 (+)
A/J MGP_AJ_G0026470
protein coding gene Chr2:128490080-128597801 (+)
AKR/J MGP_AKRJ_G0026445
protein coding gene Chr2:132192519-132301368 (+)
BALB/cJ MGP_BALBcJ_G0026482
protein coding gene Chr2:128843834-128948129 (+)
C3H/HeJ MGP_C3HHeJ_G0026225
protein coding gene Chr2:132626803-132737595 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026927
protein coding gene Chr2:138051465-138157101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024304
protein coding gene Chr2:123231027-123336178 (+)
CAST/EiJ MGP_CASTEiJ_G0025686
protein coding gene Chr2:132880442-132988951 (+)
CBA/J MGP_CBAJ_G0026205
protein coding gene Chr2:143155767-143263412 (+)
DBA/2J MGP_DBA2J_G0026339
protein coding gene Chr2:127877083-127984900 (+)
FVB/NJ MGP_FVBNJ_G0026303
protein coding gene Chr2:126502326-126607431 (+)
LP/J MGP_LPJ_G0026444
protein coding gene Chr2:134161439-134265336 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026323
protein coding gene Chr2:147009474-147116128 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026982
protein coding gene Chr2:132151578-132260834 (+)
PWK/PhJ MGP_PWKPhJ_G0025422
protein coding gene Chr2:127430633-127538346 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025224
protein coding gene Chr2:131270969-131380542 (+)
WSB/EiJ MGP_WSBEiJ_G0025760
protein coding gene Chr2:133073620-133184499 (+)



Homology
more
  • Human Ortholog
    PTPRA, protein tyrosine phosphatase receptor type A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRA, protein tyrosine phosphatase receptor type A
  • Synonyms
    HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, RPTPA, R-PTP-alpha
  • Links
    NCBI Gene ID: 5786
    neXtProt AC: NX_P18433
    UniProt: P18433

  • Chr Location
    20p13; chr20:2864184-3039076 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 6 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit deficits in Morris water maze learning, reduced locomotor activity, and decreased anxiety.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19262 NCBI Gene Model | MGI Sequence Detail 104023 C57BL/6J ±  kb
    transcript NM_008980 RefSeq | MGI Sequence Detail 3609 ZRU/MplStud  
    polypeptide P18052 UniProt | EBI | MGI Sequence Detail 829 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013464 receptor-type tyrosine-protein phosphatase alpha
    • PDB
    • EC
    • InterPro Domains
      IPR050348 Protein-Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR050713 Receptor-type Tyrosine-protein Phosphatases/Ushers
      IPR027262 Receptor tyrosine-protein phosphatase alpha
      IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      P18052 9 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 14
      cDNA 26
      Primer pair 1
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13673, MGD-MRK-13677
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 9
      Gene Ontology 16
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory