About   Help   FAQ
Ptprc Gene Detail
Summary
  • Symbol
    Ptprc
  • Name
    protein tyrosine phosphatase receptor type C
  • Synonyms
    B220, CD45, Ly-5, Lyt-4, T200
  • Feature Type
    protein coding gene
  • IDs
    MGI:97810
    NCBI Gene: 19264
  • Alliance
    gene page
  • Transcription Start Sites
    60 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:137990599-138103446 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 60.73 cM
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3143 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97810
 protein coding gene Chr1:137990599-138103491 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016545
 protein coding gene Chr1:142071541-142194593 (-)
A/J MGP_AJ_G0016528
 protein coding gene Chr1:136570531-136684865 (-)
AKR/J MGP_AKRJ_G0016493
 protein coding gene Chr1:140677089-140795441 (-)
BALB/cJ MGP_BALBcJ_G0016488
 protein coding gene Chr1:136906010-137020615 (-)
C3H/HeJ MGP_C3HHeJ_G0016314
 protein coding gene Chr1:140775176-140892339 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016949
 protein coding gene Chr1:147068621-147200591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014660
 protein coding gene Chr1:129626003-129739525 (-)
CAST/EiJ MGP_CASTEiJ_G0015894
 protein coding gene Chr1:139931849-140054944 (-)
CBA/J MGP_CBAJ_G0016287
 protein coding gene Chr1:152138218-152266663 (-)
DBA/2J MGP_DBA2J_G0016393
 protein coding gene Chr1:135555169-135676507 (-)
FVB/NJ MGP_FVBNJ_G0016392
 protein coding gene Chr1:134214883-134329664 (-)
LP/J MGP_LPJ_G0016464
 protein coding gene Chr1:143176545-143290909 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016417
 protein coding gene Chr1:157799354-157931833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016985
 protein coding gene Chr1:140455567-140569557 (-)
PWK/PhJ MGP_PWKPhJ_G0015680
 protein coding gene Chr1:134646540-134765316 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015467
 protein coding gene Chr1:139429926-139546110 (-)
WSB/EiJ MGP_WSBEiJ_G0015957
 protein coding gene Chr1:140477063-140598648 (-)



Homology
more
  • Human Ortholog
    PTPRC, protein tyrosine phosphatase receptor type C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRC, protein tyrosine phosphatase receptor type C
  • Synonyms
    B220, CD45, CD45R, GP180, IMD105, L-CA, LCA, LY5, T200
  • Links
    NCBI Gene ID: 5788
    neXtProt AC: NX_P08575
    UniProt: P08575

  • Chr Location
    1q31.3-q32.1; chr1:198638457-198759342 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ptprc mouse models; 3 with human PTPRC associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    124 phenotypes from 23 alleles in 28 genetic backgrounds
    45 phenotypes from multigenic genotypes
    343 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    138
  • GO References
    80
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    936
  • Tissues
    97
  • cDNA Data
    236
  • Literature Summary
    233
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026395 Ensembl Gene Model | MGI Sequence Detail 112848 C57BL/6J ±  kb
    transcript ENSMUST00000183301 Ensembl | MGI Sequence Detail 5074 Not Applicable  
    polypeptide ENSMUSP00000138350 Ensembl | MGI Sequence Detail 1293 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000001006 receptor-type tyrosine-protein phosphatase C
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR013783 Immunoglobulin-like fold
      IPR050348 Protein-Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
      IPR016335 Receptor-type tyrosine-protein phosphatase C
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      P06800 16 sites, 7 N-linked glycans (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 258
      Genomic 16
      cDNA 236
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11992, MGD-MRK-12076, MGD-MRK-13679, MGD-MRK-1864, MGI:3584395
    References
    more
    • Summaries
      All 769
      Developmental Gene Expression 233
      Diseases 2
      Gene Ontology 80
      Phenotypes 343
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:359553 Presa M, et al., Bone marrow transplantation increases sulfatase activity in somatic tissues in a multiple sulfatase deficiency mouse model. Commun Med (Lond). 2024 Oct 25;4(1):215
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory