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Ptprg Gene Detail
Summary
  • Symbol
    Ptprg
  • Name
    protein tyrosine phosphatase receptor type G
  • Synonyms
    5430405N12Rik, RPTPgamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:97814
    NCBI Gene: 19270
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:10227722-10916220 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 6.33 cM, cytoband A2
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20616 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97814
 protein coding gene Chr14:10227722-10916341 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PTPRG, protein tyrosine phosphatase receptor type G
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRG, protein tyrosine phosphatase receptor type G
  • Synonyms
    HPTPG, PTPG, RPTPG, R-PTP-GAMMA
  • Links
    NCBI Gene ID: 5793
    neXtProt AC: NX_P23470
    UniProt: P23470

  • Chr Location
    3p14.2; chr3:61561569-62297609 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are overtly normal but exhibit minor behavioral changes including specific motor deficits, reduced latency to react in the tail flick test, enhanced sensory processing for acoustic stimuli, and reduced performance with cued fear conditioning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    64
  • Tissues
    42
  • cDNA Data
    148
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000121513 Ensembl Gene Model | MGI Sequence Detail 688499 C57BL/6J ±  kb
transcript ENSMUST00000248537 Ensembl | MGI Sequence Detail 9192 Not Applicable  
polypeptide ENSMUSP00000159543 Ensembl | MGI Sequence Detail 1442 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    26 Sequences
  • Protein Ontology
    PR:000013470 receptor-type tyrosine-protein phosphatase gamma
    (term hierarchy)
  • PDB
    3JXG, 3KLD, 5E5U
  • EC
    3.1.3.48
  • InterPro Domains
    IPR001148 Alpha carbonic anhydrase domain
    IPR036398 Alpha carbonic anhydrase domain superfamily
    IPR023561 Carbonic anhydrase, alpha-class
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
    IPR050348 Protein-Tyrosine Phosphatase
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR041887 Receptor-type tyrosine-protein phosphatase, carbonic anhydrase domain
    IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
    IPR000387 Tyrosine-specific protein phosphatases domain
  • GlyGen
    Q05909 8 sites, 5 N-linked glycans (6 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 154
    Genomic 3
    cDNA 148
    Primer pair 2
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-13683, MGI:1918574, MGI:2145785, MGI:2145832
References
more
  • Summaries
    All 61
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:4318 Wary KK, et al., A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells. Cancer Res. 1993 Apr 1;53(7):1498-502
  • Latest
    J:350495 Taki S, et al., Novel RPTPgamma and RPTPzeta splice variants from mixed neuron-astrocyte hippocampal cultures as well as from the hippocampi of newborn and adult mice. Front Physiol. 2024;15:1406448
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory