Pvalb MGI Mouse Gene Detail - MGI:97821

Symbol

Pvalb
Name

parvalbumin
Synonyms

Parv, PV, Pva

Feature Type

protein coding gene
IDs

MGI:97821
NCBI Gene: 19293
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr15:78075314-78090600 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.93 cM, cytoband E
Mapping Data

12 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97821	protein coding gene	Chr15:78075312-78090600 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022037	protein coding gene	Chr15:78353479-78368803 (-)
A/J	MGP_AJ_G0021997	protein coding gene	Chr15:75623879-75639119 (-)
AKR/J	MGP_AKRJ_G0021974	protein coding gene	Chr15:77699949-77715196 (-)
BALB/cJ	MGP_BALBcJ_G0022005	protein coding gene	Chr15:75639448-75654730 (-)
C3H/HeJ	MGP_C3HHeJ_G0021776	protein coding gene	Chr15:77778109-77793417 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022447	protein coding gene	Chr15:81427158-81442770 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019976	protein coding gene	Chr15:72189477-72204836 (-)
CAST/EiJ	MGP_CASTEiJ_G0021296	protein coding gene	Chr15:78390644-78405911 (-)
CBA/J	MGP_CBAJ_G0021741	protein coding gene	Chr15:83940288-83955596 (-)
DBA/2J	MGP_DBA2J_G0021869	protein coding gene	Chr15:75120507-75135711 (-)
FVB/NJ	MGP_FVBNJ_G0021848	protein coding gene	Chr15:74113149-74129404 (-)
LP/J	MGP_LPJ_G0021938	protein coding gene	Chr15:78523222-78538456 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021868	protein coding gene	Chr15:89135890-89152032 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022461	protein coding gene	Chr15:77806831-77822063 (-)
PWK/PhJ	MGP_PWKPhJ_G0021038	protein coding gene	Chr15:75104990-75120380 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020874	protein coding gene	Chr15:77569258-77584496 (-)
WSB/EiJ	MGP_WSBEiJ_G0021349	protein coding gene	Chr15:78125274-78140538 (-)

Human Ortholog

PVALB, parvalbumin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PVALB, parvalbumin
Synonyms

D22S749
Links

HGNC:9704

NCBI Gene ID: 5816

neXtProt AC: NX_P20472

UniProt: P20472
Chr Location

22q12.3; chr22:36800684-36819499 (-) GRCh38

MGI Vertebrate Homology

Pvalb stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PVALB
Gene Tree

Pvalb

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Mutations/Alleles

1 with disease annotations

References

3 with disease annotations

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Phenotype Summary

4 phenotypes from 6 alleles in 7 genetic backgrounds
44 phenotypes from multigenic genotypes
1452 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

2
Radiation induced

2
Targeted

17
Genomic Mutations

3 involving Pvalb
Find Mice (IMSR)

29 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for deletion of this marker show slower cotraction-relaxation of fast twitch muscle and and increased force generation. Abnormalities are also reported in Purkinje cell morphology.

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All GO Annotations

16
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1327
Tissues

252
cDNA Data

86
Literature Summary

472

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PVALB

Xenbase pvalb

ZFIN pvalb6, pvalb7

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All Sequences

54
RefSeq

4
UniProt

3
CCDS

CCDS27609.1

Ensembl

ENSMUSG00000005716 (Evidence)
NCBI Gene

19293

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005716	Ensembl Gene Model \| MGI Sequence Detail	15287	C57BL/6J	± kb
transcript	ENSMUST00000120592	Ensembl \| MGI Sequence Detail	953	Not Applicable
polypeptide	ENSMUSP00000112598	Ensembl \| MGI Sequence Detail	110	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013502 parvalbumin alpha

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR008080 Parvalbumin

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All nucleic 115

Genomic 13

cDNA 90

Primer pair 8

Other 4

Microarray probesets 5

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MGD-MRK-13692

Summaries

All 1981

Developmental Gene Expression 472

Diseases 3

Gene Ontology 11

Phenotypes 1452
Earliest

J:7524 Stuhlfauth I, et al., Calcium-binding protein, parvalbumin, is reduced in mutant mammalian muscle with abnormal contractile properties. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4814-8
Latest

J:359037 Jablonska J, et al., Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus. Matrix Biol. 2024 Nov 2;

TSS for Pvalb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135186	Chr15:78090591-78090607 (-)	1 bp
Tssr135185	Chr15:78088629-78088650 (-)	1,960 bp
Tssr135184	Chr15:78088428-78088439 (-)	2,166 bp
Tssr135183	Chr15:78088348-78088398 (-)	2,227 bp
Tssr135182	Chr15:78085872-78085883 (-)	4,722 bp
Tssr135181	Chr15:78084877-78084881 (-)	5,721 bp
Tssr135180	Chr15:78075891-78075902 (-)	14,703 bp
Tssr135179	Chr15:78075829-78075865 (-)	14,753 bp
Tssr135178	Chr15:78075826-78075827 (-)	14,773 bp
Tssr135177	Chr15:78075753-78075762 (-)	14,842 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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