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Raf1 Gene Detail
Summary
  • Symbol
    Raf1
  • Name
    v-raf-leukemia viral oncogene 1
  • Synonyms
    6430402F14Rik, c-Raf, Craf1, Raf-1, sarcoma 3611 oncogene, v-Raf
  • Feature Type
    protein coding gene
  • IDs
    MGI:97847
    NCBI Gene: 110157
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:115595530-115653596 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.62 cM, cytoband C3
  • Mapping Data
    54 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1107 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97847
 protein coding gene Chr6:115595028-115653596 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031152
 protein coding gene Chr6:118248781-118313275 (-)
A/J MGP_AJ_G0031121
 protein coding gene Chr6:113707656-113768248 (-)
AKR/J MGP_AKRJ_G0031052
 protein coding gene Chr6:116768381-116831285 (-)
BALB/cJ MGP_BALBcJ_G0031132
 protein coding gene Chr6:113521662-113581514 (-)
C3H/HeJ MGP_C3HHeJ_G0030576
 protein coding gene Chr6:67473015-67534393 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031591
 protein coding gene Chr6:121258493-121332000 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028755
 protein coding gene Chr6:110720200-110778550 (-)
CAST/EiJ MGP_CASTEiJ_G0030239
 protein coding gene Chr6:117128336-117190179 (-)
CBA/J MGP_CBAJ_G0030818
 protein coding gene Chr6:126015366-126086992 (-)
DBA/2J MGP_DBA2J_G0030971
 protein coding gene Chr6:112638925-112697584 (-)
FVB/NJ MGP_FVBNJ_G0030925
 protein coding gene Chr6:111811373-111874026 (-)
LP/J MGP_LPJ_G0031051
 protein coding gene Chr6:118264205-118327250 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030959
 protein coding gene Chr6:130217337-130277902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031618
 protein coding gene Chr6:116784902-116847184 (-)
PWK/PhJ MGP_PWKPhJ_G0029955
 protein coding gene Chr6:111647791-111707204 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029783
 protein coding gene Chr6:115500235-115562544 (-)
WSB/EiJ MGP_WSBEiJ_G0030323
 protein coding gene Chr6:117044646-117110514 (-)



Homology
more
  • Human Ortholog
    RAF1, Raf-1 proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAF1, Raf-1 proto-oncogene, serine/threonine kinase
  • Synonyms
    CMD1NN, c-Raf, CRAF, NS5, Raf-1
  • Links
    NCBI Gene ID: 5894
    neXtProt AC: NX_P04049
    UniProt: P04049

  • Chr Location
    3p25.2; chr3:12582101-12664201 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Raf1 mouse models; 6 with human RAF1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    102 phenotypes from 9 alleles in 13 genetic backgrounds
    33 phenotypes from multigenic genotypes
    4 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are growth retarded, with hypocellular fetal livers, placental anomalies, and defects of skin and lungs, resulting in lethality around mid-gestation. Mice heterozygous for a knock-in allele exhibit hypertrophic cardiomyopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    108
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    72
  • cDNA Data
    16
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110157 NCBI Gene Model | MGI Sequence Detail 58067 C57BL/6J ±  kb
    transcript NM_001356333 RefSeq | MGI Sequence Detail 3130 ZRU/MplStud  
    polypeptide Q99N57 UniProt | EBI | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003244 RAF proto-oncogene serine/threonine-protein kinase
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR020454 Diacylglycerol/phorbol-ester binding
      IPR017441 Protein kinase, ATP binding site
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR003116 Raf-like Ras-binding
      IPR051681 Serine/Threonine Kinases and Pseudokinases
      IPR050167 Serine/threonine-protein kinase
      IPR008271 Serine/threonine-protein kinase, active site
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR029071 Ubiquitin-like domain superfamily
    • GlyGen
      Q99N57 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 4
      cDNA 21
      Primer pair 3
      Other 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13751, MGD-MRK-13752, MGI:1277195, MGI:1924126, MGI:2141729, MGI:2146790
    References
    more
    • Summaries
      All 257
      Developmental Gene Expression 25
      Diseases 3
      Gene Ontology 39
      Phenotypes 67
    • Earliest
      J:7145 Rapp UR, et al., Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4218-22
    • Latest
      J:353442 Luo X, et al., Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells. BMC Biol. 2024 Aug 26;22(1):176
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory