Rbp4 MGI Mouse Gene Detail - MGI:97879 - retinol binding protein 4, plasma

Symbol

Rbp4
Name

retinol binding protein 4, plasma
Synonyms

Rbp-4, retinol binding protein 4, cellular

Feature Type

protein coding gene
IDs

MGI:97879
NCBI Gene: 19662
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr19:38105077-38113729 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 32.75 cM, cytoband D1
Mapping Data

12 experiments

SNPs within 2kb

414 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97879	protein coding gene	Chr19:38105068-38113769 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025088	protein coding gene	Chr19:37137192-37145795 (-)
A/J	MGP_AJ_G0025064	protein coding gene	Chr19:35334867-35343470 (-)
AKR/J	MGP_AKRJ_G0025032	protein coding gene	Chr19:36536363-36544965 (-)
BALB/cJ	MGP_BALBcJ_G0025062	protein coding gene	Chr19:35443478-35452081 (-)
C3H/HeJ	MGP_C3HHeJ_G0024821	protein coding gene	Chr19:36608881-36617484 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025503	protein coding gene	Chr19:38201352-38210041 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022922	protein coding gene	Chr19:34690403-34699062 (-)
CAST/EiJ	MGP_CASTEiJ_G0024288	protein coding gene	Chr19:36477566-36486234 (-)
CBA/J	MGP_CBAJ_G0024798	protein coding gene	Chr19:39982593-39991196 (-)
DBA/2J	MGP_DBA2J_G0024930	protein coding gene	Chr19:35188681-35197316 (-)
FVB/NJ	MGP_FVBNJ_G0024891	protein coding gene	Chr19:35001423-35010021 (-)
LP/J	MGP_LPJ_G0025016	protein coding gene	Chr19:37234832-37243435 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024922	protein coding gene	Chr19:39763292-39772934 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025561	protein coding gene	Chr19:36635152-36643755 (-)
PWK/PhJ	MGP_PWKPhJ_G0024040	protein coding gene	Chr19:35054520-35063224 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023840	protein coding gene	Chr19:35472162-35480751 (-)
WSB/EiJ	MGP_WSBEiJ_G0024355	protein coding gene	Chr19:36717801-36726401 (-)

Human Ortholog

RBP4, retinol binding protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBP4, retinol binding protein 4
Synonyms

MCOPCB10, RDCCAS
Links

HGNC:9922

NCBI Gene ID: 5950

neXtProt AC: NX_P02753

UniProt: P02753
Chr Location

10q23.33; chr10:93591687-93601744 (-) GRCh38

MGI Vertebrate Homology

Rbp4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBP4
Protein SuperFamily

Lipocalin_ApoD
Gene Tree

Rbp4

Diseases

2 with human RBP4 associations

				Human Disease	Mouse Models
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 5 alleles in 5 genetic backgrounds
4 phenotypes from multigenic genotypes
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

5
Gene trapped

1
Targeted

9
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a null allele show abnormal retinal function and retinol level, delayed heart trabeculation, and increased myocyte proliferation and fibronectin deposition in cardiac jelly and nascent valves. Homozygotes for another null allele show testicular defects on a vitamin A-deficient diet.

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All GO Annotations

56
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

886
Tissues

97
cDNA Data

177
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RBP4

Xenbase rbp4

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All Sequences

48
RefSeq

4
UniProt

5
CCDS

CCDS29784.1, CCDS50430.1

Ensembl

ENSMUSG00000024990 (Evidence)
NCBI Gene

19662

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024990	Ensembl Gene Model \| MGI Sequence Detail	8653	C57BL/6J	± kb
transcript	ENSMUST00000025951	Ensembl \| MGI Sequence Detail	1161	Not Applicable
polypeptide	ENSMUSP00000025951	Ensembl \| MGI Sequence Detail	245	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013821 retinol-binding protein 4

(term hierarchy)
InterPro Domains

IPR012674 Calycin

IPR022271 Lipocalin, ApoD type

IPR000566 Lipocalin/cytosolic fatty-acid binding domain

IPR022272 Lipocalin family conserved site

IPR002449 Retinol binding protein/Purpurin
GlyGen

Q00724 1 site, 1 O-linked glycan (1 site)

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All nucleic 187

cDNA 179

Primer pair 5

Other 3

Microarray probesets 3

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MGD-MRK-13790, MGD-MRK-13795

Summaries

All 124

Developmental Gene Expression 25

Diseases 1

Gene Ontology 17

Phenotypes 46
Earliest

J:11060 Chainani M, et al., Localization of the gene for plasma retinol binding protein to the distal half of mouse chromosome 19. Genomics. 1991 Feb;9(2):376-9
Latest

J:346630 Zhang X, et al., Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature. Commun Biol. 2024 Mar 23;7(1):363

TSS for Rbp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159128	Chr19:38113706-38113754 (-)	-1 bp
Tssr159127	Chr19:38113693-38113702 (-)	31 bp
Tssr159126	Chr19:38113682-38113688 (-)	44 bp
Tssr159125	Chr19:38113249-38113264 (-)	472 bp
Tssr159124	Chr19:38113085-38113125 (-)	624 bp
Tssr159123	Chr19:38113001-38113022 (-)	717 bp
Tssr159122	Chr19:38112858-38112883 (-)	858 bp
Tssr159121	Chr19:38112812-38112831 (-)	907 bp
Tssr159120	Chr19:38112777-38112802 (-)	939 bp
Tssr159119	Chr19:38112531-38112579 (-)	1,174 bp
Tssr159118	Chr19:38112498-38112507 (-)	1,226 bp
Tssr159117	Chr19:38106928-38106939 (-)	6,795 bp
Tssr159116	Chr19:38106830-38106925 (-)	6,851 bp
Tssr159115	Chr19:38106794-38106823 (-)	6,920 bp
Tssr159114	Chr19:38106755-38106767 (-)	6,968 bp
Tssr159113	Chr19:38105315-38105364 (-)	8,389 bp
Tssr159112	Chr19:38105260-38105299 (-)	8,449 bp
Tssr159111	Chr19:38105221-38105249 (-)	8,494 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24