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Rdx Gene Detail
Summary
  • Symbol
    Rdx
  • Name
    radixin
  • Feature Type
    protein coding gene
  • IDs
    MGI:97887
    NCBI Gene: 19684
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:51958450-52000038 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 28.62 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1110 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97887
 protein coding gene Chr9:51958450-52011763 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034804
 protein coding gene Chr9:51021648-51063885 (+)
A/J MGP_AJ_G0034785
 protein coding gene Chr9:49431072-49473816 (+)
AKR/J MGP_AKRJ_G0034713
 protein coding gene Chr9:50478936-50520441 (+)
BALB/cJ MGP_BALBcJ_G0034777
 protein coding gene Chr9:49187625-49229583 (+)
C3H/HeJ MGP_C3HHeJ_G0034487
 protein coding gene Chr9:50978164-51019653 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035296
 protein coding gene Chr9:52433720-52477586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032209
 protein coding gene Chr9:48871401-48913058 (+)
CAST/EiJ MGP_CASTEiJ_G0033809
 protein coding gene Chr9:50936059-50980022 (+)
CBA/J MGP_CBAJ_G0034458
 protein coding gene Chr9:54253514-54294973 (+)
DBA/2J MGP_DBA2J_G0034617
 protein coding gene Chr9:49288694-49330733 (+)
FVB/NJ MGP_FVBNJ_G0034559
 protein coding gene Chr9:48503064-48545519 (+)
LP/J MGP_LPJ_G0034699
 protein coding gene Chr9:51349191-51391862 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034602
 protein coding gene Chr9:55849863-55891925 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035318
 protein coding gene Chr9:50475969-50517425 (+)
PWK/PhJ MGP_PWKPhJ_G0033513
 protein coding gene Chr9:49279558-49321826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033349
 protein coding gene Chr9:50758475-50800650 (+)
WSB/EiJ MGP_WSBEiJ_G0033921
 protein coding gene Chr9:50474927-50517398 (+)



Homology
more
  • Human Ortholog
    RDX, radixin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RDX, radixin
  • Synonyms
    DFNB24
  • Links
    NCBI Gene ID: 5962
    neXtProt AC: NX_P35241
    UniProt: P35241

  • Chr Location
    11q22.3; chr11:109864295-110296712 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rdx mouse models; 1 with human RDX associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display mild degenerative changes in the liver and hyperbilirubinemia. Adult homozygotes exhibit profound deafness, but not imbalance, associated with progressive degeneration of stereocilia of cochlear hair cells after the onset of hearing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    62
  • cDNA Data
    19
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19684 NCBI Gene Model | MGI Sequence Detail 41589 C57BL/6J ±  kb
    transcript NM_009041 RefSeq | MGI Sequence Detail 4224 C57BL/6  
    polypeptide P26043 UniProt | EBI | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13819, MGI:2142943
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 20
      Phenotypes 20
    • Earliest
      J:35128 Funayama N, et al., Radixin is a novel member of the band 4.1 family. J Cell Biol. 1991 Nov;115(4):1039-48
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory