Ren1 MGI Mouse Gene Detail - MGI:97898

Symbol

Ren1
Name

renin 1 structural
Synonyms

Ren, Ren-1, Ren1c, Ren1d, Ren-A, Rn-1, Rnr

Feature Type

protein coding gene
IDs

MGI:97898
NCBI Gene: 19701
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:133278412-133288058 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.91 cM
Mapping Data

32 experiments

SNPs within 2kb

295 from dbSNP Build 142
Strain Annotations

16
PCR

2
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97898	protein coding gene	Chr1:133278248-133288063 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016485	protein coding gene	Chr1:136897826-136929005 (+)
A/J	MGP_AJ_G0016468	protein coding gene	Chr1:131808228-131818043 (+)
AKR/J	MGP_AKRJ_G0016433	protein coding gene	Chr1:135707939-135721314 (+)
BALB/cJ	MGP_BALBcJ_G0016428	protein coding gene	Chr1:132140193-132150008 (+)
C3H/HeJ	MGP_C3HHeJ_G0016254	protein coding gene	Chr1:135829976-135839783 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016889	protein coding gene	Chr1:141957786-141969405 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014600	protein coding gene	Chr1:124958073-124967851 (+)
CAST/EiJ	MGP_CASTEiJ_G0015834	protein coding gene	Chr1:134857280-134868431 (+)
CBA/J	MGP_CBAJ_G0016228	protein coding gene	Chr1:146817105-146840559 (+)
DBA/2J	MGP_DBA2J_G0016333	protein coding gene	Chr1:130778986-130824931 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0016404	protein coding gene	Chr1:138198595-138222890 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016357	protein coding gene	Chr1:152562073-152606260 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016925	protein coding gene	Chr1:135434617-135449484 (+)
PWK/PhJ	MGP_PWKPhJ_G0015620	protein coding gene	Chr1:129807633-129814869 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0015896	protein coding gene	Chr1:135447660-135469030 (+)

Human Ortholog

REN, renin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REN, renin
Synonyms

ADTKD4, HNFJ2, RTD
Links

HGNC:9958

NCBI Gene ID: 5972

neXtProt AC: NX_P00797

UniProt: P00797
Chr Location

1q32.1; chr1:204154819-204190324 (-) GRCh38

MGI Vertebrate Homology

Ren1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: REN
Gene Tree

Ren1

Diseases

5 with human REN associations

				Human Disease	Mouse Models
				essential hypertension IDs essential hypertension DOID:10825 ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:D000075222 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 UMLS_CUI:C0085580
				familial juvenile hyperuricemic nephropathy IDs familial juvenile hyperuricemic nephropathy DOID:0060062 OMIM:162000 OMIM:613092 OMIM:614227 ORDO:209886 ORDO:217330
				hand, foot and mouth disease IDs hand, foot and mouth disease DOID:10881 ICD10CM:B08.4 ICD9CM:074.3 MESH:D006232 NCI:C128439 UMLS_CUI:C0018572
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				portal hypertension IDs portal hypertension DOID:10762 ICD10CM:K76.6 ICD9CM:572.3 MESH:D006975 NCI:C3119 UMLS_CUI:C0020541

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

69 phenotypes from 10 alleles in 11 genetic backgrounds
14 phenotypes from multigenic genotypes
2 images
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

4
Radiation induced

1
Targeted

13
Transgenic

2
Genomic Mutations

3 involving Ren1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous inactivation of this gene leads to postnatal lethality, reduced plasma renin level, decreased mean arterial pressure, and kidney defects such as atrophy, altered juxtaglomerular cell and macula densa morphology, polyuria, decreased urine osmolality, and reduced glomerular filtration rate.

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All GO Annotations

50
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1034
Tissues

136
cDNA Data

11
Literature Summary

45

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ren

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS15295.1

Ensembl

ENSMUSG00000070645 (Evidence)
NCBI Gene

19701

			Length	Strain/Species	Flank
genomic	19701	NCBI Gene Model \| MGI Sequence Detail	9647	C57BL/6J	± kb
transcript	NM_031192	RefSeq \| MGI Sequence Detail	1423	ZRU/MplStud
polypeptide	P06281	UniProt \| EBI \| MGI Sequence Detail	402	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014394 renin-1

(term hierarchy)
PDB

5MKT
EC

3.4.23.15
InterPro Domains

IPR001461 Aspartic peptidase A1 family

IPR001969 Aspartic peptidase, active site

IPR021109 Aspartic peptidase domain superfamily

IPR012848 Aspartic peptidase, N-terminal

IPR033121 Peptidase family A1 domain

IPR034135 Renin-like domain
GlyGen

P06281 3 sites

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All nucleic 55

Genomic 16

cDNA 21

Primer pair 14

Other 4

Microarray probesets 2

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MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13836, MGD-MRK-13838, MGD-MRK-13917, MGD-MRK-13951, MGI:2138723

Summaries

All 255

Developmental Gene Expression 45

Gene Ontology 15

Phenotypes 77
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:338389 Belyea BC, et al., Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype. Clin Sci (Lond). 2023 Jan 13;137(1):35-45

TSS for Ren1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr212	Chr1:133278023-133278038 (+)	-381 bp
Tssr8801	Chr1:133278405-133278421 (+)	1 bp
Tssr8802	Chr1:133280248-133280267 (+)	1,846 bp
Tssr8803	Chr1:133281948-133281977 (+)	3,551 bp
Tssr8804	Chr1:133287992-133288003 (+)	9,586 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24