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Ret Gene Detail
Summary
  • Symbol
    Ret
  • Name
    ret proto-oncogene
  • Synonyms
    c-Ret, RET51, RET9
  • Feature Type
    protein coding gene
  • IDs
    MGI:97902
    NCBI Gene: 19713
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:118128706-118174679 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 55.86 cM, cytoband E3-F1
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1384 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97902
 protein coding gene Chr6:118128706-118174705 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031184
 protein coding gene Chr6:120893072-120943417 (-)
A/J MGP_AJ_G0031153
 protein coding gene Chr6:116263329-116310463 (-)
AKR/J MGP_AKRJ_G0031084
 protein coding gene Chr6:119392552-119438427 (-)
BALB/cJ MGP_BALBcJ_G0031164
 protein coding gene Chr6:116044001-116091337 (-)
C3H/HeJ MGP_C3HHeJ_G0030545
 protein coding gene Chr6:64855301-64902192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031622
 protein coding gene Chr6:124007284-124056702 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028784
 protein coding gene Chr6:113194916-113240621 (-)
CAST/EiJ MGP_CASTEiJ_G0030271
 protein coding gene Chr6:119774134-119827059 (-)
CBA/J MGP_CBAJ_G0030847
 protein coding gene Chr6:128889512-128945328 (-)
DBA/2J MGP_DBA2J_G0031003
 protein coding gene Chr6:115166625-115211562 (-)
FVB/NJ MGP_FVBNJ_G0030955
 protein coding gene Chr6:114299894-114346396 (-)
LP/J MGP_LPJ_G0031082
 protein coding gene Chr6:120921187-120978192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030989
 protein coding gene Chr6:132997155-133046643 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031651
 protein coding gene Chr6:119420125-119473647 (-)
PWK/PhJ MGP_PWKPhJ_G0029986
 protein coding gene Chr6:114182242-114228469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029815
 protein coding gene Chr6:118142813-118188614 (-)
WSB/EiJ MGP_WSBEiJ_G0030354
 protein coding gene Chr6:119688316-119735517 (-)



Homology
more
  • Human Ortholog
    RET, ret proto-oncogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RET, ret proto-oncogene
  • Synonyms
    CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1
  • Links
    NCBI Gene ID: 5979
    neXtProt AC: NX_P07949
    UniProt: P07949

  • Chr Location
    10q11.21; chr10:43077064-43130351 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Ret mouse models; 6 with human RET associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 2 models
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
 View 2 "NOT" models
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    125 phenotypes from 32 alleles in 33 genetic backgrounds
    42 phenotypes from multigenic genotypes
    233 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some point mutations or knock-out alleles exhibit premature lethality, defects in neurogenesis, and abnormal kidney, ureter, ovary, muscle, and intestine morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    119
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2103
  • Tissues
    503
  • cDNA Data
    48
  • Literature Summary
    432
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030110 Ensembl Gene Model | MGI Sequence Detail 45974 C57BL/6J ±  kb
    transcript ENSMUST00000032201 Ensembl | MGI Sequence Detail 5456 Not Applicable  
    polypeptide ENSMUSP00000032201 Ensembl | MGI Sequence Detail 1115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013895 proto-oncogene tyrosine-protein kinase receptor Ret
      (term hierarchy)
    • PDB
      1UEF
    • EC
      2.7.10.1
    • InterPro Domains
      IPR002126 Cadherin-like
      IPR015919 Cadherin-like superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR041163 Ret, cadherin like domain 1
      IPR041317 RET, cadherin-like domain 4
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR040667 Tyrosine-protein kinase receptor Ret, cadherin like domain 3
      IPR016249 Tyrosine-protein kinase, Ret receptor
    • GlyGen
      P35546 16 sites, 3 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 129
      Genomic 2
      cDNA 55
      Primer pair 28
      Other 44

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13846
    References
    more
    • Summaries
      All 691
      Developmental Gene Expression 432
      Diseases 6
      Gene Ontology 34
      Phenotypes 233
    • Earliest
      J:10540 Takahashi M, et al., Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene. 1988 Nov;3(5):571-8
    • Latest
      J:359304 Lemmetyinen TT, et al., Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation. iScience. 2024 Dec 20;27(12):111246
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory