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Rnase1 Gene Detail
Summary
  • Symbol
    Rnase1
  • Name
    ribonuclease, RNase A family, 1 (pancreatic)
  • Synonyms
    Rib-1, Rib1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97919
    NCBI Gene: 19752
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51382459-51384224 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 26.40 cM, cytoband B-C1
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97919
 protein coding gene Chr14:51382455-51384242 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021275
 protein coding gene Chr14:45112773-45114535 (-)
A/J MGP_AJ_G0021230
 protein coding gene Chr14:43755968-43757730 (-)
AKR/J MGP_AKRJ_G0021206
 protein coding gene Chr14:45411732-45413494 (-)
BALB/cJ MGP_BALBcJ_G0021233
 protein coding gene Chr14:43889865-43891627 (-)
C3H/HeJ MGP_C3HHeJ_G0021015
 protein coding gene Chr14:45229605-45231367 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021669
 protein coding gene Chr14:46967490-46969255 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019220
 protein coding gene Chr14:43087071-43088808 (-)
CAST/EiJ MGP_CASTEiJ_G0020538
 protein coding gene Chr14:42301622-42303383 (-)
CBA/J MGP_CBAJ_G0020982
 protein coding gene Chr14:48413329-48415091 (-)
DBA/2J MGP_DBA2J_G0021106
 protein coding gene Chr14:43650543-43652305 (-)
FVB/NJ MGP_FVBNJ_G0021085
 protein coding gene Chr14:43284367-43286129 (-)
LP/J MGP_LPJ_G0021173
 protein coding gene Chr14:45399360-45401122 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021113
 protein coding gene Chr14:47931972-47933734 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021698
 protein coding gene Chr14:44889953-44891715 (-)
PWK/PhJ MGP_PWKPhJ_G0020288
 protein coding gene Chr14:40569549-40571311 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020113
 protein coding gene Chr14:41068267-41070031 (-)
WSB/EiJ MGP_WSBEiJ_G0020591
 protein coding gene Chr14:45094953-45096715 (-)



Homology
more
  • Human Ortholog
    RNASE1, ribonuclease A family member 1, pancreatic
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNASE1, ribonuclease A family member 1, pancreatic
  • Synonyms
    RAC1, RIB1, RNS1
  • Links
    NCBI Gene ID: 6035
    neXtProt AC: NX_P07998
    UniProt: P07998

  • Chr Location
    14q11.2; chr14:20801228-20802855 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased weight, quickler plasma clotting and elevated FXII and FXI activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    48
  • cDNA Data
    140
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19752 NCBI Gene Model | MGI Sequence Detail 1766 C57BL/6J ±  kb
    transcript NM_011271 RefSeq | MGI Sequence Detail 970 ZRU/MplStud  
    polypeptide P00683 UniProt | EBI | MGI Sequence Detail 149 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 147
      Genomic 3
      cDNA 142
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13876, MGD-MRK-13877, MGI:2145673
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:8319 Elliott RW, et al., Assignment of pancreatic ribonuclease gene to mouse chromosome 14. Cytogenet Cell Genet. 1986;42(1-2):110-2
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory