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Rpn2 Gene Detail
Summary
  • Symbol
    Rpn2
  • Name
    ribophorin II
  • Synonyms
    1300012C06Rik, Rpn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98085
    NCBI Gene: 20014
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157121018-157168238 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.20 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2784 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98085
 protein coding gene Chr2:157120937-157168239 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026779
 protein coding gene Chr2:162274287-162322786 (+)
A/J MGP_AJ_G0026745
 protein coding gene Chr2:155783703-155834417 (+)
AKR/J MGP_AKRJ_G0026716
 protein coding gene Chr2:160372966-160420239 (+)
BALB/cJ MGP_BALBcJ_G0026754
 protein coding gene Chr2:156077717-156126023 (+)
C3H/HeJ MGP_C3HHeJ_G0026496
 protein coding gene Chr2:160681019-160734324 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027203
 protein coding gene Chr2:167101405-167150705 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024573
 protein coding gene Chr2:149241995-149289697 (+)
CAST/EiJ MGP_CASTEiJ_G0025958
 protein coding gene Chr2:161022413-161071770 (+)
CBA/J MGP_CBAJ_G0026473
 protein coding gene Chr2:173116818-173164211 (+)
DBA/2J MGP_DBA2J_G0026611
 protein coding gene Chr2:154966001-155013330 (+)
FVB/NJ MGP_FVBNJ_G0026578
 protein coding gene Chr2:153353163-153401140 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0026599
 protein coding gene Chr2:176966957-177014964 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027259
 protein coding gene Chr2:160184815-160234155 (+)
PWK/PhJ MGP_PWKPhJ_G0025692
 protein coding gene Chr2:154480813-154528823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025495
 protein coding gene Chr2:159138163-159185842 (+)
WSB/EiJ MGP_WSBEiJ_G0026028
 protein coding gene Chr2:161074321-161126881 (+)



Homology
more
  • Human Ortholog
    RPN2, ribophorin II
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPN2, ribophorin II
  • Synonyms
    RIBIIR, RPN-II, RPNII, SWP1
  • Links
    NCBI Gene ID: 6185
    neXtProt AC: NX_P04844
    UniProt: P04844

  • Chr Location
    20q11.23; chr20:37178410-37241619 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    96
  • cDNA Data
    502
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20014 NCBI Gene Model | MGI Sequence Detail 47221 C57BL/6J ±  kb
    transcript NM_001355163 RefSeq | MGI Sequence Detail 2764 ZRU/MplStud  
    polypeptide Q9DBG6 UniProt | EBI | MGI Sequence Detail 631 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014241 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
      (term hierarchy)
    • PDB
      5J6G, 5J6H
    • InterPro Domains
      IPR008814 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1
    • GlyGen
      Q9DBG6 2 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 506
      cDNA 503
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14108, MGD-MRK-14110, MGI:1914153, MGI:2139263
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:4880 Barton DE, et al., The genes for ribophorins I and II are on human Chromosomes 3q and 20 and mouse Chromosomes 6 and 2, respectively. Cytogenet Cell Genet. 1987;46:577 (Abstr.)
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory