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Polr2a Gene Detail
Summary
  • Symbol
    Polr2a
  • Name
    polymerase (RNA) II (DNA directed) polypeptide A
  • Synonyms
    220kDa, Rpo2-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98086
    NCBI Gene: 20020
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69624823-69649459 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B1-C
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    460 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98086
 protein coding gene Chr11:69624823-69649463 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018551
 protein coding gene Chr11:70206649-70234731 (-)
A/J MGP_AJ_G0018519
 protein coding gene Chr11:67554297-67580108 (-)
AKR/J MGP_AKRJ_G0018488
 protein coding gene Chr11:69573130-69597783 (-)
BALB/cJ MGP_BALBcJ_G0018491
 protein coding gene Chr11:67870599-67900615 (-)
C3H/HeJ MGP_C3HHeJ_G0018304
 protein coding gene Chr11:69602654-69628054 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018942
 protein coding gene Chr11:72328622-72353238 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016587
 protein coding gene Chr11:64474158-64500200 (-)
CAST/EiJ MGP_CASTEiJ_G0017859
 protein coding gene Chr11:69843074-69867554 (-)
CBA/J MGP_CBAJ_G0018277
 protein coding gene Chr11:75567898-75596235 (-)
DBA/2J MGP_DBA2J_G0018386
 protein coding gene Chr11:67135672-67160890 (-)
FVB/NJ MGP_FVBNJ_G0018376
 protein coding gene Chr11:66777855-66803091 (-)
LP/J MGP_LPJ_G0018456
 protein coding gene Chr11:70771937-70799639 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018399
 protein coding gene Chr11:76181718-76207893 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018984
 protein coding gene Chr11:69834792-69860811 (-)
PWK/PhJ MGP_PWKPhJ_G0017633
 protein coding gene Chr11:67784891-67811436 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017423
 protein coding gene Chr11:69654809-69681069 (-)
WSB/EiJ MGP_WSBEiJ_G0017913
 protein coding gene Chr11:69500179-69528459 (-)



Homology
more
  • Human Ortholog
    POLR2A, RNA polymerase II subunit A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2A, RNA polymerase II subunit A
  • Synonyms
    hRPB220, hsRPB1, NEDHIB, POLR2, POLRA, RPB1, RPBh1, RpIILS, RPO2, RPOL2
  • Links
    NCBI Gene ID: 5430
    neXtProt AC: NX_P24928
    UniProt: P24928

  • Chr Location
    17p13.1; chr17:7484366-7514616 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 5 alleles in 4 genetic backgrounds
    69 phenotypes from multigenic genotypes
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a reporter allele show prenatal lethality. Homozygotes for a small deletion in the C-terminal domain are viable, fertile and developmentally normal. Homozygotes for a larger deletion show reduced fetal size and partial postnatal lethality; survivors are small but otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    121
  • cDNA Data
    131
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20020 NCBI Gene Model | MGI Sequence Detail 24637 C57BL/6J ±  kb
    transcript NM_001291068 RefSeq | MGI Sequence Detail 6736 C57BL/6  
    polypeptide P08775 UniProt | EBI | MGI Sequence Detail 1970 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 153
      Genomic 17
      cDNA 132
      Primer pair 1
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14111
    References
    more
    • Summaries
      All 226
      Developmental Gene Expression 39
      Diseases 1
      Gene Ontology 21
      Phenotypes 118
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354953 Kula B, et al., D--hydroxybutyrate stabilizes hippocampal CA3-CA1 circuit during acute insulin resistance. PNAS Nexus. 2024 May;3(5):pgae196
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory