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Rps12 Gene Detail
Summary
  • Symbol
    Rps12
  • Name
    ribosomal protein S12
  • Feature Type
    protein coding gene
  • IDs
    MGI:98105
    NCBI Gene: 20042
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:23661081-23663173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 11.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98105
 protein coding gene Chr10:23661042-23664297 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017072
 protein coding gene Chr10:21701333-21709160 (-)
A/J MGP_AJ_G0017050
 protein coding gene Chr10:21090495-21092479 (-)
AKR/J MGP_AKRJ_G0017012
 protein coding gene Chr10:21434210-21436194 (-)
BALB/cJ MGP_BALBcJ_G0017012
 protein coding gene Chr10:21165065-21168992 (-)
C3H/HeJ MGP_C3HHeJ_G0016832
 protein coding gene Chr10:21632153-21634137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017470
 protein coding gene Chr10:22346886-22348870 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015171
 protein coding gene Chr10:19815471-19817524 (-)
CAST/EiJ MGP_CASTEiJ_G0016413
 protein coding gene Chr10:21524511-21526548 (-)
CBA/J MGP_CBAJ_G0016805
 protein coding gene Chr10:23354484-23356468 (-)
DBA/2J MGP_DBA2J_G0016911
 protein coding gene Chr10:20819505-20821489 (-)
FVB/NJ MGP_FVBNJ_G0016907
 protein coding gene Chr10:20544397-20546381 (-)
LP/J MGP_LPJ_G0016987
 protein coding gene Chr10:21690669-21693421 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016937
 protein coding gene Chr10:23498057-23501674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017505
 protein coding gene Chr10:21282559-21284543 (-)
PWK/PhJ MGP_PWKPhJ_G0016198
 protein coding gene Chr10:20564541-20566767 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015980
 protein coding gene Chr10:21094865-21098436 (-)
WSB/EiJ MGP_WSBEiJ_G0016476
 protein coding gene Chr10:21390285-21394111 (-)



Homology
more
  • Human Ortholog
    RPS12, ribosomal protein S12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS12, ribosomal protein S12
  • Synonyms
    eS12, S12
  • Links
    NCBI Gene ID: 6206
    neXtProt AC: NX_P25398
    UniProt: P25398

  • Chr Location
    6q23.2; chr6:132814569-132817564 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit defective erythropoiesis and hematopoietic stem cell maintenance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061983 Ensembl Gene Model | MGI Sequence Detail 2093 C57BL/6J ±  kb
    transcript ENSMUST00000218221 Ensembl | MGI Sequence Detail 460 Not Applicable  
    polypeptide ENSMUSP00000151586 Ensembl | MGI Sequence Detail 148 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014253 small ribosomal subunit protein eS12
      (term hierarchy)
    • PDB
      7LS1, 7LS2
    • InterPro Domains
      IPR029064 Ribosomal protein eL30-like superfamily
      IPR004038 Ribosomal protein eL8/eL30/eS12/Gadd45
      IPR000530 Small ribosomal subunit protein eS12
      IPR047860 Small ribosomal subunit protein eS12, conserved site
    • GlyGen
      P63323 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 13

      Microarray probesets 19
    Other
    Accession IDs
    less
    MGD-MRK-14131
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:338970 Folgado-Marco V, et al., Haploinsufficiency of the essential gene Rps12 causes defects in erythropoiesis and hematopoietic stem cell maintenance. Elife. 2023 Jun 5;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory