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Rps4x Gene Detail
Summary
  • Symbol
    Rps4x
  • Name
    ribosomal protein S4, X-linked
  • Synonyms
    Rps4, Rps4-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98158
    NCBI Gene: 20102
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:101228548-101232929 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 45.20 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98158
 protein coding gene ChrX:101228547-101233000 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035971
 protein coding gene ChrX:98767914-98772367 (-)
A/J MGP_AJ_G0035956
 protein coding gene ChrX:98721257-98726163 (-)
AKR/J MGP_AKRJ_G0035872
 protein coding gene ChrX:101579883-101588039 (-)
BALB/cJ MGP_BALBcJ_G0035941
 protein coding gene ChrX:97462551-97467133 (-)
C3H/HeJ MGP_C3HHeJ_G0035649
 protein coding gene ChrX:99146347-99150800 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036469
 protein coding gene ChrX:101697444-101701897 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033298
 protein coding gene ChrX:96433178-96437747 (-)
CAST/EiJ MGP_CASTEiJ_G0034935
 protein coding gene ChrX:83462201-83466661 (-)
CBA/J MGP_CBAJ_G0035623
 protein coding gene ChrX:104848629-104853075 (-)
DBA/2J MGP_DBA2J_G0035777
 protein coding gene ChrX:97944086-97948540 (-)
FVB/NJ MGP_FVBNJ_G0035716
 protein coding gene ChrX:97305898-97310679 (-)
LP/J MGP_LPJ_G0035868
 protein coding gene ChrX:99685944-99692783 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035750
 protein coding gene ChrX:109368830-109375490 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036495
 protein coding gene ChrX:98419628-98424075 (-)
PWK/PhJ MGP_PWKPhJ_G0034634
 protein coding gene ChrX:81031004-81035561 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034462
 protein coding gene ChrX:84368881-84373673 (-)
WSB/EiJ MGP_WSBEiJ_G0035074
 protein coding gene ChrX:97124647-97129723 (-)



Homology
more
  • Human Ortholog
    RPS4X, ribosomal protein S4 X-linked
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS4X, ribosomal protein S4 X-linked
  • Synonyms
    CCG2, DXS306, eS4, RPS4, S4, SCAR, SCR10
  • Links
    NCBI Gene ID: 6191
    neXtProt AC: NX_P62701
    UniProt: P62701

  • Chr Location
    Xq13.1; chrX:72255679-72277248 (-)  GRCh38
  • Human Ortholog
    RPS4Y1, ribosomal protein S4 Y-linked 1
  • Synonyms
    RPS4Y, S4
  • Links
    NCBI Gene ID: 6192
    neXtProt AC: NX_P22090
    UniProt: P22090

  • Chr Location
    Yp11.2; chrY:2841602-2932000 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Rps4x, Ube1x, and Zfx are subject to X-inactivation in mouse but not in human, suggesting that Turner syncrome may be in part due to insufficiency in these gene products.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    51
  • cDNA Data
    865
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20102 NCBI Gene Model | MGI Sequence Detail 4382 C57BL/6J ±  kb
transcript NM_001425995 RefSeq | MGI Sequence Detail 1298 C57BL/6  
polypeptide P62702 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014277 small ribosomal subunit protein eS4, X isoform
    (term hierarchy)
  • PDB
    7CPU, 7CPV, 7LS1, 7LS2
  • InterPro Domains
    IPR005824 KOW
    IPR014722 Large ribosomal subunit protein uL2, domain 2
    IPR002942 RNA-binding S4 domain
    IPR036986 RNA-binding S4 domain superfamily
    IPR000876 Small ribosomal subunit protein eS4
    IPR038237 Small ribosomal subunit protein eS4, central domain superfamily
    IPR013845 Small ribosomal subunit protein eS4, central region
    IPR032277 Small ribosomal subunit protein eS4, C-terminal domain
    IPR041982 Small ribosomal subunit protein eS4, KOW domain
    IPR013843 Small ribosomal subunit protein eS4, N-terminal
    IPR018199 Small ribosomal subunit protein eS4, N-terminal, conserved site
  • GlyGen
    P62702 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 870
    Genomic 2
    cDNA 866
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-14174, MGD-MRK-14185
References
more
  • Summaries
    All 50
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 2
  • Earliest
    J:10892 Fisher EM, et al., Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. Cell. 1990 Dec 21;63(6):1205-18
  • Latest
    J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory