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Rras Gene Detail
Summary
  • Symbol
    Rras
  • Name
    related RAS viral (r-ras) oncogene
  • Synonyms
    Rras1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98179
    NCBI Gene: 20130
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44667385-44671071 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.08 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98179
 protein coding gene Chr7:44665686-44671071 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032194
 protein coding gene Chr7:45243692-45249099 (+)
A/J MGP_AJ_G0032173
 protein coding gene Chr7:44387555-44392960 (+)
AKR/J MGP_AKRJ_G0032109
 protein coding gene Chr7:45611853-45617380 (+)
BALB/cJ MGP_BALBcJ_G0032185
 protein coding gene Chr7:44381793-44387181 (+)
C3H/HeJ MGP_C3HHeJ_G0031901
 protein coding gene Chr7:46113568-46118954 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032677
 protein coding gene Chr7:47513038-47518557 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029691
 protein coding gene Chr7:46950904-46956491 (+)
CAST/EiJ MGP_CASTEiJ_G0031229
 protein coding gene Chr7:37482704-37488274 (+)
CBA/J MGP_CBAJ_G0031865
 protein coding gene Chr7:49064770-49070154 (+)
DBA/2J MGP_DBA2J_G0032023
 protein coding gene Chr7:44055876-44061405 (+)
FVB/NJ MGP_FVBNJ_G0031974
 protein coding gene Chr7:43834559-43840072 (+)
LP/J MGP_LPJ_G0032101
 protein coding gene Chr7:45917053-45922443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032011
 protein coding gene Chr7:47787205-47794059 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032693
 protein coding gene Chr7:44830341-44835746 (+)
PWK/PhJ MGP_PWKPhJ_G0030952
 protein coding gene Chr7:37420096-37425500 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030789
 protein coding gene Chr7:32837229-32842804 (+)
WSB/EiJ MGP_WSBEiJ_G0031346
 protein coding gene Chr7:45310955-45314589 (+)



Homology
more
  • Human Ortholog
    RRAS, RAS related
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRAS, RAS related
  • Synonyms
    R-Ras, RRAS1
  • Links
    NCBI Gene ID: 6237
    neXtProt AC: NX_P10301
    UniProt: P10301

  • Chr Location
    19q13.33; chr19:49635292-49640143 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote and heterozygote null mice are lymphopenic, resulting from diminished homeostatic proliferation and impaired T cell and B cell survival. Mice homozygous for a gene-trapped allele exhibit enhanced neointimal thickening in response to arterial injury, increased angiogenesis in matrigel plugs and aortic ring cultures, and increased neovascularization of tumor implants, and decreased B-cell and increased T-cell population percentages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    53
  • cDNA Data
    67
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038387 Ensembl Gene Model | MGI Sequence Detail 3687 C57BL/6J ±  kb
    transcript ENSMUST00000044111 Ensembl | MGI Sequence Detail 995 Not Applicable  
    polypeptide ENSMUSP00000042150 Ensembl | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 67
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14208, MGI:2142000
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:23421 Sakaguchi AY, et al., R-ras: A member of the ras family on human Chromosome 19. Am J Hum Genet. 1986;39(Suppl):A167 (Abstr.)
    • Latest
      J:348798 Herrera JL, et al., Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1. Cell Rep. 2024 Feb 24;43(3):113837
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory