Saac Gene Detail

Summary

• Symbol
  Saac
• Name
  sialic acid O-acetylation

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:98225
  NCBI Gene: 109990
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 9, Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

This locus controls susceptibility of erythrocytes to lysis via the human alternate complement pathway. This susceptibility is correlated among inbred strains with the degree of O-acetylation of sialic acid in erythocytes.

Sequences &
Gene Models

• NCBI Gene
  109990

Other
Accession IDs

MGD-MRK-14283

References

• Summaries
  All 5
• Earliest
  J:32410 Nydegger UE, et al., Autosomal locus regulates inverse relationship between sialic acid content and capacity of mouse erythrocytes to activate human alternative complement pathway. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6078-82
• Latest
  J:33387 Guimaraes MJ, et al., Molecular cloning and characterization of lysosomal sialic acid O-acetylesterase. J Biol Chem. 1996 Jun 7;271(23):13697-705