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Stmn2 Gene Detail
Summary
  • Symbol
    Stmn2
  • Name
    stathmin-like 2
  • Synonyms
    SCG10, Scgn10
  • Feature Type
    protein coding gene
  • IDs
    MGI:98241
    NCBI Gene: 20257
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:8574587-8626664 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 2.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1402 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98241
 protein coding gene Chr3:8574420-8626666 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027052
 protein coding gene Chr3:5337216-5393059 (+)
A/J MGP_AJ_G0027016
 protein coding gene Chr3:5598779-5652253 (+)
AKR/J MGP_AKRJ_G0026986
 protein coding gene Chr3:5474671-5529483 (+)
BALB/cJ MGP_BALBcJ_G0027025
 protein coding gene Chr3:5318185-5371434 (+)
C3H/HeJ MGP_C3HHeJ_G0026765
 protein coding gene Chr3:5726092-5778663 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027469
 protein coding gene Chr3:5924358-5987369 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024831
 protein coding gene Chr3:4597251-4645452 (+)
CAST/EiJ MGP_CASTEiJ_G0026223
 protein coding gene Chr3:5739477-5796030 (+)
CBA/J MGP_CBAJ_G0026743
 protein coding gene Chr3:5822282-5879122 (+)
DBA/2J MGP_DBA2J_G0026879
 protein coding gene Chr3:5199336-5249332 (+)
FVB/NJ MGP_FVBNJ_G0026846
 protein coding gene Chr3:5076256-5126277 (+)
LP/J MGP_LPJ_G0026989
 protein coding gene Chr3:5851183-5907611 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026866
 protein coding gene Chr3:6977210-7035287 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027529
 protein coding gene Chr3:5299538-5353206 (+)
PWK/PhJ MGP_PWKPhJ_G0025958
 protein coding gene Chr3:5390836-5441105 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025761
 protein coding gene Chr3:5438566-5489926 (+)
WSB/EiJ MGP_WSBEiJ_G0026294
 protein coding gene Chr3:5309263-5363337 (+)



Homology
more
  • Human Ortholog
    STMN2, stathmin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STMN2, stathmin 2
  • Synonyms
    SCG10, SCGN10
  • Links
    NCBI Gene ID: 11075
    neXtProt AC: NX_Q93045
    UniProt: Q93045

  • Chr Location
    8q21.13; chr8:79611117-79666158 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Stmn2 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 2 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop early-onset sensory and motor neuropathy with behavioral deficits, reduced compound muscle action potentials, severe distal neuromuscular junction (NMJ) denervation of fast-fatigable motor units, and intraepidermal nerve fiber loss. Heterozygous null mice show a progressive, motor-selective neuropathy with distal NMJ denervation but no sensory defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1174
  • Tissues
    140
  • cDNA Data
    170
  • Literature Summary
    92
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20257 NCBI Gene Model | MGI Sequence Detail 52078 C57BL/6J ±  kb
    transcript NM_025285 RefSeq | MGI Sequence Detail 1904 ZRU/MplStud  
    polypeptide P55821 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 204
      Genomic 16
      cDNA 176
      Primer pair 1
      Other 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-14310, MGI:2139640
    References
    more
    • Summaries
      All 156
      Developmental Gene Expression 92
      Diseases 1
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:2523 Pampfer S, et al., Differential mRNA expression of the phosphoprotein p19/SCG10 gene family in mouse preimplantation embryos, uterus, and placenta. Reprod Fertil Dev. 1992;4(2):205-11
    • Latest
      J:348862 Lopez-Erauskin J, et al., Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation. Nat Neurosci. 2024 Jan;27(1):34-47
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory