Ccl4 MGI Mouse Gene Detail - MGI:98261 - C-C motif chemokine ligand 4

Symbol

Ccl4
Name

C-C motif chemokine ligand 4
Synonyms

Act-2, AT744.1, Mip1b, MIP-1B, MIP-1 beta, Scya4

Feature Type

protein coding gene
IDs

MGI:98261
NCBI Gene: 20303
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr11:83553410-83555509 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.09 cM
Mapping Data

12 experiments

SNPs within 2kb

131 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98261	protein coding gene	Chr11:83553410-83555509 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018857	protein coding gene	Chr11:85026588-85028696 (+)
A/J	MGP_AJ_G0018824	protein coding gene	Chr11:81775110-81777218 (+)
AKR/J	MGP_AKRJ_G0018794	protein coding gene	Chr11:84213385-84215490 (+)
BALB/cJ	MGP_BALBcJ_G0018797	protein coding gene	Chr11:82192028-82194127 (+)
C3H/HeJ	MGP_C3HHeJ_G0018611	protein coding gene	Chr11:84274833-84276941 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019249	protein coding gene	Chr11:87613288-87615387 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016882	protein coding gene	Chr11:78890216-78892330 (+)
CAST/EiJ	MGP_CASTEiJ_G0018166	protein coding gene	Chr11:84852680-84854767 (+)
CBA/J	MGP_CBAJ_G0018582	protein coding gene	Chr11:91382790-91384898 (+)
DBA/2J	MGP_DBA2J_G0018690	protein coding gene	Chr11:81373556-81375661 (+)
FVB/NJ	MGP_FVBNJ_G0018679	protein coding gene	Chr11:80860158-80862257 (+)
LP/J	MGP_LPJ_G0018760	protein coding gene	Chr11:85568196-85570304 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018706	protein coding gene	Chr11:91546731-91548830 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019289	protein coding gene	Chr11:84493164-84495263 (+)
PWK/PhJ	MGP_PWKPhJ_G0017935	protein coding gene	Chr11:82133009-82135117 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017727	protein coding gene	Chr11:84017327-84021155 (+)
WSB/EiJ	MGP_WSBEiJ_G0018217	protein coding gene	Chr11:84345269-84347368 (+)

Human Ortholog

CCL4, C-C motif chemokine ligand 4

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL4, C-C motif chemokine ligand 4
Synonyms

ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP1B, MIP1B1, MIP-1-beta, SCYA2, SCYA4
Links

HGNC:10630

NCBI Gene ID: 6351

neXtProt AC: NX_P13236

UniProt: P13236
Chr Location

17q12; chr17:36103827-36105621 (+) GRCh38

Human Ortholog

CCL4L1, C-C motif chemokine ligand 4 like 1
Synonyms

AT744.2, CCL4L, LAG-1, LAG1, MIP-1-beta, SCYA4L, SCYA4L1, SCYA4L2
Links

HGNC:10631

NCBI Gene ID: 388372

neXtProt AC: NX_P13236, NX_Q8NHW4

UniProt: Q8NHW4
Chr Location

17q12; chr17:36210924-36212878 (+) GRCh38

Human Ortholog

CCL4L2, C-C motif chemokine ligand 4 like 2
Synonyms

AT744.2, CCL4L, SCYA4L, SCYQ4L2
Links

HGNC:24066

NCBI Gene ID: 9560

neXtProt AC: NX_Q8NHW4
Chr Location

17q12; chr17:36210924-36212878 (+) GRCh38

MGI Vertebrate Homology

Ccl4 stringent orthology
3 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCL4, CCL4L1, CCL4L2
Gene Tree

Ccl4

Diseases

2 with human CCL4,CCL4L2 associations

				Human Disease	Mouse Models
				acquired immunodeficiency syndrome IDs acquired immunodeficiency syndrome DOID:635 EFO:0000765 ICD10CM:B20 MESH:D000163 NCI:C2851 UMLS_CUI:C0001175
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

6
Targeted

2
Transgenic

3
Genomic Mutations

2 involving Ccl4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice with induced diabetic kidney disease show improved renal function, decreased renal glomerulosclerosis and fibrosis, decreased renal inflammation and reduced blood sugar levels compared to controls.

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

771
Tissues

42
cDNA Data

13
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccl4

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All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS36256.1

Ensembl

ENSMUSG00000018930 (Evidence)
NCBI Gene

20303

			Length	Strain/Species	Flank
genomic	20303	NCBI Gene Model \| MGI Sequence Detail	2100	C57BL/6J	± kb
transcript	NM_013652	RefSeq \| MGI Sequence Detail	674	ZRU/MplStud
polypeptide	P14097	UniProt \| EBI \| MGI Sequence Detail	92	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002124 C-C motif chemokine 4

(term hierarchy)
InterPro Domains

IPR000827 CC chemokine, conserved site

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

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All nucleic 18

Genomic 4

cDNA 14

Microarray probesets 2

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MGD-MRK-12242, MGD-MRK-14335

Summaries

All 95

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346348 Chang TT, et al., Macrophage inflammatory protein-1beta as a novel therapeutic target for renal protection in diabetic kidney disease. Biomed Pharmacother. 2023 Feb 28;161:114450

TSS for Ccl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103733	Chr11:83553360-83553370 (+)	-45 bp
Tssr103734	Chr11:83553382-83553385 (+)	-26 bp
Tssr103735	Chr11:83553405-83553420 (+)	3 bp
Tssr103736	Chr11:83554271-83554299 (+)	875 bp
Tssr103737	Chr11:83554300-83554303 (+)	892 bp
Tssr103738	Chr11:83554306-83554326 (+)	906 bp
Tssr103739	Chr11:83554397-83554405 (+)	991 bp
Tssr103740	Chr11:83555131-83555165 (+)	1,738 bp
Tssr103741	Chr11:83555214-83555309 (+)	1,852 bp
Tssr103742	Chr11:83555311-83555339 (+)	1,915 bp
Tssr103743	Chr11:83555391-83555403 (+)	1,987 bp
Tssr103744	Chr11:83555425-83555438 (+)	2,022 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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