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Epha4 Gene Detail
Summary
  • Symbol
    Epha4
  • Name
    Eph receptor A4
  • Synonyms
    2900005C20Rik, Cek8, Hek8, rb, Sek, Sek1, Tyro1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98277
    NCBI Gene: 13838
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:77343822-77491725 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 39.55 cM, cytoband C1-C5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98277
 protein coding gene Chr1:77343819-77491763 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016195
 protein coding gene Chr1:78038489-78189818 (-)
A/J MGP_AJ_G0016178
 protein coding gene Chr1:75309807-75455170 (-)
AKR/J MGP_AKRJ_G0016135
 protein coding gene Chr1:77364281-77514407 (-)
BALB/cJ MGP_BALBcJ_G0016133
 protein coding gene Chr1:75390459-75541518 (-)
C3H/HeJ MGP_C3HHeJ_G0015964
 protein coding gene Chr1:77721334-77865659 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016586
 protein coding gene Chr1:81053366-81213081 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014307
 protein coding gene Chr1:70779309-70925699 (-)
CAST/EiJ MGP_CASTEiJ_G0015548
 protein coding gene Chr1:77099829-77250640 (-)
CBA/J MGP_CBAJ_G0015937
 protein coding gene Chr1:83702766-83854333 (-)
DBA/2J MGP_DBA2J_G0016038
 protein coding gene Chr1:74623209-74764726 (-)
FVB/NJ MGP_FVBNJ_G0016041
 protein coding gene Chr1:73804516-73946527 (-)
LP/J MGP_LPJ_G0016110
 protein coding gene Chr1:79173425-79318852 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016061
 protein coding gene Chr1:86997533-87151351 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016633
 protein coding gene Chr1:77491370-77643454 (-)
PWK/PhJ MGP_PWKPhJ_G0015335
 protein coding gene Chr1:74090948-74236985 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015113
 protein coding gene Chr1:76817810-76976856 (-)
WSB/EiJ MGP_WSBEiJ_G0015610
 protein coding gene Chr1:77282343-77430531 (-)



Homology
more
  • Human Ortholog
    EPHA4, EPH receptor A4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHA4, EPH receptor A4
  • Synonyms
    EK8, HEK8, SEK, TYRO1
  • Links
    NCBI Gene ID: 2043
    neXtProt AC: NX_P54764
    UniProt: P54764

  • Chr Location
    2q36.1; chr2:221418027-221574202 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 14 alleles in 21 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections resulting in a hopping gait. Heterozygotes show a less severe phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    172
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1833
  • Tissues
    579
  • cDNA Data
    43
  • Literature Summary
    226
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026235 Ensembl Gene Model | MGI Sequence Detail 147904 C57BL/6J ±  kb
    transcript ENSMUST00000027451 Ensembl | MGI Sequence Detail 6328 Not Applicable  
    polypeptide ENSMUSP00000027451 Ensembl | MGI Sequence Detail 986 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 50
      Primer pair 6
      Other 24

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-14356, MGD-MRK-38166, MGI:109122, MGI:1920161, MGI:2138218
    References
    more
    • Summaries
      All 391
      Developmental Gene Expression 226
      Gene Ontology 31
      Phenotypes 119
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346126 Pappas MP, et al., Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development. 2024 Mar 1;151(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory