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Sell Gene Detail
Summary
  • Symbol
    Sell
  • Name
    selectin, lymphocyte
  • Synonyms
    CD62L, LECAM-1, Lnhr, L-selectin, Ly-22, Lyam-1, Lyam1, Ly-m22
  • Feature Type
    protein coding gene
  • IDs
    MGI:98279
    NCBI Gene: 20343
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:163889556-163908354 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 71.37 cM
  • Mapping Data
    41 experiments
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98279
 protein coding gene Chr1:163889551-163911750 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016678
 protein coding gene Chr1:169476633-169498832 (+)
A/J MGP_AJ_G0016659
 protein coding gene Chr1:162572168-162594367 (+)
AKR/J MGP_AKRJ_G0016625
 protein coding gene Chr1:167507368-167529567 (+)
BALB/cJ MGP_BALBcJ_G0016620
 protein coding gene Chr1:163072749-163094948 (+)
C3H/HeJ MGP_C3HHeJ_G0016444
 protein coding gene Chr1:167685267-167707466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017081
 protein coding gene Chr1:175178193-175200392 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014790
 protein coding gene Chr1:154556805-154579872 (+)
CAST/EiJ MGP_CASTEiJ_G0016024
 protein coding gene Chr1:167325674-167347865 (+)
CBA/J MGP_CBAJ_G0016419
 protein coding gene Chr1:181406769-181428958 (+)
DBA/2J MGP_DBA2J_G0016525
 protein coding gene Chr1:161466893-161489390 (+)
FVB/NJ MGP_FVBNJ_G0016523
 protein coding gene Chr1:159919771-159942142 (+)
LP/J MGP_LPJ_G0016596
 protein coding gene Chr1:170555853-170578052 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016548
 protein coding gene Chr1:188924668-188947033 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017117
 protein coding gene Chr1:167330773-167353229 (+)
PWK/PhJ MGP_PWKPhJ_G0015810
 protein coding gene Chr1:160656778-160679008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015597
 protein coding gene Chr1:166207672-166231686 (+)
WSB/EiJ MGP_WSBEiJ_G0016086
 protein coding gene Chr1:167495894-167518094 (+)



Homology
more
  • Human Ortholog
    SELL, selectin L
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SELL, selectin L
  • Synonyms
    CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1
  • Links
    NCBI Gene ID: 6402
    neXtProt AC: NX_P14151
    UniProt: P14151

  • Chr Location
    1q24.2; chr1:169690665-169711702 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sell mouse models; 3 with human SELL associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 12 alleles in 16 genetic backgrounds
    38 phenotypes from multigenic genotypes
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit lack of lymphocyte binding to high endothelial venules of peripheral lymph nodes and defects in leukocyte rolling and neutrophil migration into the peritoneum following an inflammatory stimulus. Tumor cell survival is also reduced. Homozygosity for an amino-acid substitution results in enhanced peripheral blood neutrophil inflammatory response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    6
  • cDNA Data
    36
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20343 NCBI Gene Model | MGI Sequence Detail 18799 C57BL/6J ±  kb
    transcript NM_011346 RefSeq | MGI Sequence Detail 2341 ZRU/MplStud  
    polypeptide P18337 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 3
      cDNA 36

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11841, MGD-MRK-11961, MGD-MRK-12014, MGD-MRK-12052, MGD-MRK-12053, MGD-MRK-14358, MGI:2138287
    References
    more
    • Summaries
      All 260
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 20
      Phenotypes 135
    • Earliest
      J:7544 Tada N, et al., Mouse alloantigen system Ly-m22 predominantly expressed on T lymphocytes and controlled by a gene linked to M1s region on chromosome 1. Hybridoma. 1983;2(1):29-38
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory