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Selp Gene Detail
Summary
  • Symbol
    Selp
  • Name
    selectin, platelet
  • Synonyms
    CD62P, Grmp, P-selectin
  • Feature Type
    protein coding gene
  • IDs
    MGI:98280
    NCBI Gene: 20344
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:163942833-163977595 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 71.42 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1212 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98280
 protein coding gene Chr1:163942833-163977595 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016679
 protein coding gene Chr1:169532277-169572837 (+)
A/J MGP_AJ_G0016660
 protein coding gene Chr1:162625299-162660887 (+)
AKR/J MGP_AKRJ_G0016626
 protein coding gene Chr1:167561240-167597814 (+)
BALB/cJ MGP_BALBcJ_G0016621
 protein coding gene Chr1:163125941-163161145 (+)
C3H/HeJ MGP_C3HHeJ_G0016445
 protein coding gene Chr1:167749702-167788160 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017082
 protein coding gene Chr1:175232081-175268452 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014791
 protein coding gene Chr1:154611320-154645552 (+)
CAST/EiJ MGP_CASTEiJ_G0016025
 protein coding gene Chr1:167382904-167420239 (+)
CBA/J MGP_CBAJ_G0016420
 protein coding gene Chr1:181465548-181511078 (+)
DBA/2J MGP_DBA2J_G0016526
 protein coding gene Chr1:161520035-161556499 (+)
FVB/NJ MGP_FVBNJ_G0016524
 protein coding gene Chr1:159972278-160007061 (+)
LP/J MGP_LPJ_G0016597
 protein coding gene Chr1:170609927-170647325 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016549
 protein coding gene Chr1:188980121-189017893 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017118
 protein coding gene Chr1:167388223-167429213 (+)
PWK/PhJ MGP_PWKPhJ_G0015811
 protein coding gene Chr1:160708974-160745094 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015598
 protein coding gene Chr1:166263095-166301267 (+)
WSB/EiJ MGP_WSBEiJ_G0016087
 protein coding gene Chr1:167551317-167589171 (+)



Homology
more
  • Human Ortholog
    SELP, selectin P
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SELP, selectin P
  • Synonyms
    CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL
  • Links
    NCBI Gene ID: 6403
    neXtProt AC: NX_P16109
    UniProt: P16109

  • Chr Location
    1q24.2; chr1:169588849-169630193 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SELP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 10 genetic backgrounds
    75 phenotypes from multigenic genotypes
    225 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit mildly attenuated inflammatory responses, increased numbers of circulating neutrophils, lack of leukocyte rolling in mesenteric venules, and increased survival after Plasmodium berghei infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    10
  • cDNA Data
    18
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20344 NCBI Gene Model | MGI Sequence Detail 34763 C57BL/6J ±  kb
    transcript NM_011347 RefSeq | MGI Sequence Detail 3438 ZRU/MplStud  
    polypeptide Q01102 UniProt | EBI | MGI Sequence Detail 768 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 19
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10271, MGD-MRK-14360
    References
    more
    • Summaries
      All 349
      Developmental Gene Expression 9
      Gene Ontology 20
      Phenotypes 225
    • Earliest
      J:4461 Popp RA, Linkage of Es-1 and Es-2 in the mouse. J Hered. 1967;58(4):186-188
    • Latest
      J:354028 Ballard-Kordeliski A, et al., 4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model. Blood. 2024 Sep 5;144(10):1116-1126
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory