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Spi1 Gene Detail
Summary
  • Symbol
    Spi1
  • Name
    Spi-1 proto-oncogene
  • Synonyms
    Dis-1, PU.1, Sfpi-1, Sfpi1, Spi-1, spleen focus forming virus (SFFV) proviral integration oncogene, Tcfpu1, Tfpu.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98282
    NCBI Gene: 20375
  • Alliance
    gene page
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:90912750-90946104 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.44 cM, cytoband E3
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    776 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98282
 protein coding gene Chr2:90912735-90946104 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026141
 protein coding gene Chr2:92389098-92422359 (+)
A/J MGP_AJ_G0026102
 protein coding gene Chr2:88691831-88727038 (+)
AKR/J MGP_AKRJ_G0026083
 protein coding gene Chr2:91144790-91178073 (+)
BALB/cJ MGP_BALBcJ_G0026111
 protein coding gene Chr2:88856452-88904563 (+)
C3H/HeJ MGP_C3HHeJ_G0025862
 protein coding gene Chr2:91420443-91455959 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026562
 protein coding gene Chr2:95635753-95674793 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023953
 protein coding gene Chr2:85207276-85240764 (+)
CAST/EiJ MGP_CASTEiJ_G0025327
 protein coding gene Chr2:91944732-91979558 (+)
CBA/J MGP_CBAJ_G0025840
 protein coding gene Chr2:98899020-98933234 (+)
DBA/2J MGP_DBA2J_G0025976
 protein coding gene Chr2:88293094-88326083 (+)
FVB/NJ MGP_FVBNJ_G0025939
 protein coding gene Chr2:87395404-87430335 (+)
LP/J MGP_LPJ_G0026080
 protein coding gene Chr2:92594867-92631459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025965
 protein coding gene Chr2:101936027-101972038 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026616
 protein coding gene Chr2:91204226-91241572 (+)
PWK/PhJ MGP_PWKPhJ_G0025062
 protein coding gene Chr2:88021061-88055141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024863
 protein coding gene Chr2:90783593-90817092 (+)
WSB/EiJ MGP_WSBEiJ_G0025394
 protein coding gene Chr2:91798208-91836834 (+)



Homology
more
  • Human Ortholog
    SPI1, Spi-1 proto-oncogene
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPI1, Spi-1 proto-oncogene
  • Synonyms
    AGM10, OF, PU.1, SFPI1, SPI-1, SPI-A
  • Links
    NCBI Gene ID: 6688
    neXtProt AC: NX_P17947
    UniProt: P17947

  • Chr Location
    11p11.2; chr11:47354860-47409369 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Spi1 mouse models; 1 with human SPI1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    97 phenotypes from 17 alleles in 21 genetic backgrounds
    17 phenotypes from multigenic genotypes
    172 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice may exhibit fetal or perinatal lethality, absence of myeloid and B cells, and altered T cell and NK cell development. Mice carrying hypomorphic alleles display impaired B-cell and myeloid development, develop T cell derived lymphomas andacute myeloid leukemia, and die prematurely.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    112
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1057
  • Tissues
    273
  • cDNA Data
    44
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20375 NCBI Gene Model | MGI Sequence Detail 33355 C57BL/6J ±  kb
    transcript NM_011355 RefSeq | MGI Sequence Detail 1473 C57BL/6  
    polypeptide P17433 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 21
      cDNA 44
      Primer pair 8
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14369, MGD-MRK-14370, MGD-MRK-14764, MGD-MRK-15047
    References
    more
    • Summaries
      All 393
      Developmental Gene Expression 43
      Diseases 1
      Gene Ontology 44
      Phenotypes 172
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:348384 Kim B, et al., Effects of SPI1-mediated transcriptome remodeling on Alzheimer's disease-related phenotypes in mouse models of Abeta amyloidosis. Nat Commun. 2024 May 11;15(1):3996
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory