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Srsf3 Gene Detail
Summary
  • Symbol
    Srsf3
  • Name
    serine and arginine-rich splicing factor 3
  • Synonyms
    Sfrs3, X16
  • Feature Type
    protein coding gene
  • IDs
    MGI:98285
    NCBI Gene: 20383
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29251634-29262346 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.03 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98285
 protein coding gene Chr17:29251602-29262347 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023456
 protein coding gene Chr17:28531839-28542485 (+)
A/J MGP_AJ_G0023414
 protein coding gene Chr17:27546700-27556256 (+)
AKR/J MGP_AKRJ_G0023379
 protein coding gene Chr17:27775933-27790200 (+)
BALB/cJ MGP_BALBcJ_G0023419
 protein coding gene Chr17:27830234-27843392 (+)
C3H/HeJ MGP_C3HHeJ_G0023180
 protein coding gene Chr17:28162752-28174299 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023861
 protein coding gene Chr17:29663064-29673288 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021336
 protein coding gene Chr17:24892426-24901538 (+)
CAST/EiJ MGP_CASTEiJ_G0022681
 protein coding gene Chr17:28145787-28156629 (+)
CBA/J MGP_CBAJ_G0023154
 protein coding gene Chr17:30749382-30766780 (+)
DBA/2J MGP_DBA2J_G0023285
 protein coding gene Chr17:27089700-27102782 (+)
FVB/NJ MGP_FVBNJ_G0023255
 protein coding gene Chr17:26917734-26928605 (+)
LP/J MGP_LPJ_G0023363
 protein coding gene Chr17:28784315-28794645 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023273
 protein coding gene Chr17:30120695-30132916 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023903
 protein coding gene Chr17:28229848-28244100 (+)
PWK/PhJ MGP_PWKPhJ_G0022431
 protein coding gene Chr17:25925557-25932289 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022249
 protein coding gene Chr17:26229454-26240594 (+)
WSB/EiJ MGP_WSBEiJ_G0022743
 protein coding gene Chr17:28202941-28204592 (+)



Homology
more
  • Human Ortholog
    SRSF3, serine and arginine rich splicing factor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRSF3, serine and arginine rich splicing factor 3
  • Synonyms
    SFRS3, SRp20
  • Links
    NCBI Gene ID: 6428
    neXtProt AC: NX_P84103
    UniProt: P84103

  • Chr Location
    6p21.31-p21.2; chr6:36594353-36605600 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    89 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die at early embryonic stages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    28
  • cDNA Data
    35
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20383 NCBI Gene Model | MGI Sequence Detail 10713 C57BL/6J ±  kb
    transcript NR_036613 RefSeq | MGI Sequence Detail 3025 C57BL/6  
    polypeptide P84104 UniProt | EBI | MGI Sequence Detail 164 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014760 serine/arginine-rich splicing factor 3
      (term hierarchy)
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR050907 Serine/Arginine-Rich Splicing Factor
    • GlyGen
      P84104 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 2
      cDNA 36
      Primer pair 5
      Other 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-14373, MGI:2146963
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:25670 Ayane M, et al., A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991 Mar 25;19(6):1273-8
    • Latest
      J:347878 Li Z, et al., FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and male fertility. Elife. 2024 Mar 12;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory