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Scg5 Gene Detail
Summary
  • Symbol
    Scg5
  • Name
    secretogranin V
  • Synonyms
    7B2, Sgne-1, Sgne1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98289
    NCBI Gene: 20394
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:113606708-113659423 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 57.45 cM, cytoband E5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1382 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98289
 protein coding gene Chr2:113606707-113659466 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026298
 protein coding gene Chr2:116250212-116307675 (-)
A/J MGP_AJ_G0026259
 protein coding gene Chr2:111523414-111571919 (-)
AKR/J MGP_AKRJ_G0026238
 protein coding gene Chr2:114628759-114680708 (-)
BALB/cJ MGP_BALBcJ_G0026272
 protein coding gene Chr2:111756754-111803451 (-)
C3H/HeJ MGP_C3HHeJ_G0026017
 protein coding gene Chr2:115047092-115098118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026719
 protein coding gene Chr2:120106716-120160641 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024099
 protein coding gene Chr2:106691833-106738017 (-)
CAST/EiJ MGP_CASTEiJ_G0025480
 protein coding gene Chr2:115354570-115404180 (-)
CBA/J MGP_CBAJ_G0025994
 protein coding gene Chr2:124299242-124355390 (-)
DBA/2J MGP_DBA2J_G0026133
 protein coding gene Chr2:110975731-111029482 (-)
FVB/NJ MGP_FVBNJ_G0026095
 protein coding gene Chr2:109836119-109881632 (-)
LP/J MGP_LPJ_G0026234
 protein coding gene Chr2:116557097-116605434 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026114
 protein coding gene Chr2:128692557-128744086 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026774
 protein coding gene Chr2:114700997-114752208 (-)
PWK/PhJ MGP_PWKPhJ_G0025216
 protein coding gene Chr2:110490228-110538572 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025015
 protein coding gene Chr2:113857402-113904373 (-)
WSB/EiJ MGP_WSBEiJ_G0025549
 protein coding gene Chr2:115523193-115572284 (-)



Homology
more
  • Human Ortholog
    SCG5, secretogranin V
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCG5, secretogranin V
  • Synonyms
    7B2, P7B2, SGNE1, SgV
  • Links
    NCBI Gene ID: 6447
    neXtProt AC: NX_P05408
    UniProt: P05408

  • Chr Location
    15q13.3; chr15:32641676-32697098 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scg5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene often die before weaning and display a variety of metabolic defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    956
  • Tissues
    52
  • cDNA Data
    48
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20394 NCBI Gene Model | MGI Sequence Detail 52716 C57BL/6J ±  kb
    transcript NM_001420947 RefSeq | MGI Sequence Detail 2991 ZRU/MplStud  
    polypeptide P12961 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 49
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14385, MGD-MRK-14386, MGI:2138903
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 9
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory