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Shb Gene Detail
Summary
  • Symbol
    Shb
  • Name
    src homology 2 domain-containing transforming protein B
  • Feature Type
    protein coding gene
  • IDs
    MGI:98294
    NCBI Gene: 230126
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:45423278-45530804 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 24.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98294
 protein coding gene Chr4:45423278-45532470 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028245
 protein coding gene Chr4:43658208-43772374 (-)
A/J MGP_AJ_G0028204
 protein coding gene Chr4:42095857-42205055 (-)
AKR/J MGP_AKRJ_G0028154
 protein coding gene Chr4:43098925-43208006 (-)
BALB/cJ MGP_BALBcJ_G0028224
 protein coding gene Chr4:42182833-42296750 (-)
C3H/HeJ MGP_C3HHeJ_G0027945
 protein coding gene Chr4:43707990-43821179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028665
 protein coding gene Chr4:45301424-45413873 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025974
 protein coding gene Chr4:39478455-39589642 (-)
CAST/EiJ MGP_CASTEiJ_G0027384
 protein coding gene Chr4:43254480-43368744 (-)
CBA/J MGP_CBAJ_G0027911
 protein coding gene Chr4:46715161-46833608 (-)
DBA/2J MGP_DBA2J_G0028061
 protein coding gene Chr4:41994371-42103670 (-)
FVB/NJ MGP_FVBNJ_G0028028
 protein coding gene Chr4:41220915-41331053 (-)
LP/J MGP_LPJ_G0028160
 protein coding gene Chr4:43716017-43826032 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028052
 protein coding gene Chr4:49869295-49979419 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028700
 protein coding gene Chr4:43316263-43426359 (-)
PWK/PhJ MGP_PWKPhJ_G0027109
 protein coding gene Chr4:42064465-42175152 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026937
 protein coding gene Chr4:42826728-42940806 (-)
WSB/EiJ MGP_WSBEiJ_G0027462
 protein coding gene Chr4:43219155-43331728 (-)



Homology
more
  • Human Ortholog
    SHB, SH2 domain containing adaptor protein B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHB, SH2 domain containing adaptor protein B
  • Synonyms
    bA3J10.2
  • Links
    NCBI Gene ID: 6461
    neXtProt AC: NX_Q15464
    UniProt: Q15464

  • Chr Location
    9p13.1; chr9:37915898-38069227 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some embryonic lethality associated with various embryogenesis defects including loss of embryo structures, open neural tube, hemorrhaging and tail defects. Heterozygous mice exhibit a distortion in the transmission ratio of the allele maternally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    16
  • cDNA Data
    61
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 230126 NCBI Gene Model | MGI Sequence Detail 107527 C57BL/6J ±  kb
    transcript NM_001033306 RefSeq | MGI Sequence Detail 2718 C57BL/6  
    polypeptide Q6PD21 UniProt | EBI | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 61
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14400, MGI:2448529
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:16321 Welsh M, et al., Shb is a ubiquitously expressed Src homology 2 protein. Oncogene. 1994 Jan;9(1):19-27
    • Latest
      J:339946 Galazo MJ, et al., Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity. Cell Rep. 2023 Aug 29;42(8):112957
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory