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Shc1 Gene Detail
Summary
  • Symbol
    Shc1
  • Name
    src homology 2 domain-containing transforming protein C1
  • Synonyms
    p66, p66shc, ShcA
  • Feature Type
    protein coding gene
  • IDs
    MGI:98296
    NCBI Gene: 20416
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89325858-89337336 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98296
 protein coding gene Chr3:89325750-89337336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027439
 protein coding gene Chr3:89632987-89645071 (+)
A/J MGP_AJ_G0027403
 protein coding gene Chr3:86666656-86678876 (+)
AKR/J MGP_AKRJ_G0027367
 protein coding gene Chr3:88763448-88777015 (+)
BALB/cJ MGP_BALBcJ_G0027412
 protein coding gene Chr3:86633937-86646150 (+)
C3H/HeJ MGP_C3HHeJ_G0027154
 protein coding gene Chr3:88966920-88980153 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027858
 protein coding gene Chr3:93019241-93030640 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025210
 protein coding gene Chr3:82149359-82162528 (+)
CAST/EiJ MGP_CASTEiJ_G0026600
 protein coding gene Chr3:89323415-89336000 (+)
CBA/J MGP_CBAJ_G0027128
 protein coding gene Chr3:96209022-96223365 (+)
DBA/2J MGP_DBA2J_G0027266
 protein coding gene Chr3:86044290-86056898 (+)
FVB/NJ MGP_FVBNJ_G0027234
 protein coding gene Chr3:84387257-84397009 (+)
LP/J MGP_LPJ_G0027375
 protein coding gene Chr3:90712597-90725238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027254
 protein coding gene Chr3:102418687-102430367 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027917
 protein coding gene Chr3:88519437-88532679 (+)
PWK/PhJ MGP_PWKPhJ_G0026334
 protein coding gene Chr3:85922657-85933497 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026153
 protein coding gene Chr3:87693114-87708900 (+)
WSB/EiJ MGP_WSBEiJ_G0026682
 protein coding gene Chr3:88912269-88929491 (+)



Homology
more
  • Human Ortholog
    SHC1, SHC adaptor protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHC1, SHC adaptor protein 1
  • Synonyms
    SHC, SHCA
  • Links
    NCBI Gene ID: 6464
    neXtProt AC: NX_P29353
    UniProt: P29353

  • Chr Location
    1q21.3; chr1:154962298-154974395 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 8 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes with a targeted mutation of the exon encoding the CH2 region show an extended life span, reduced cellular sensitivity to oxidative stress and UV irradiation, and resistance to diet-induced atherogenesis. Homozygotes lacking all three isoformsdie around E11.5 with cardiovascular defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    34
  • cDNA Data
    105
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20416 NCBI Gene Model | MGI Sequence Detail 11479 C57BL/6J ±  kb
    transcript NM_001113331 RefSeq | MGI Sequence Detail 3569 ZRU/MplStud  
    polypeptide P98083 UniProt | EBI | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      Genomic 1
      cDNA 109
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14402
    References
    more
    • Summaries
      All 204
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 31
      Phenotypes 90
    • Earliest
      J:17164 Pelicci G, et al., A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992 Jul 10;70(1):93-104
    • Latest
      J:345583 Lopresti L, et al., p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation. Front Cell Dev Biol. 2024;12:1297116
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory