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Sst Gene Detail
Summary
  • Symbol
    Sst
  • Name
    somatostatin
  • Synonyms
    preprosomatostatin, Smst, SOM, SRIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:98326
    NCBI Gene: 20604
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:23708323-23709708 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 15.00 cM, cytoband cen-C3
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98326
 protein coding gene Chr16:23708323-23710041 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022686
 protein coding gene Chr16:21488504-21489767 (-)
A/J MGP_AJ_G0022648
 protein coding gene Chr16:20475171-20476434 (-)
AKR/J MGP_AKRJ_G0022622
 protein coding gene Chr16:21341167-21342430 (-)
BALB/cJ MGP_BALBcJ_G0022653
 protein coding gene Chr16:20670122-20671385 (-)
C3H/HeJ MGP_C3HHeJ_G0022417
 protein coding gene Chr16:21461273-21462536 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023102
 protein coding gene Chr16:22025302-22026565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020620
 protein coding gene Chr16:21111301-21112563 (-)
CAST/EiJ MGP_CASTEiJ_G0021946
 protein coding gene Chr16:21461337-21462599 (-)
CBA/J MGP_CBAJ_G0022388
 protein coding gene Chr16:22930526-22931789 (-)
DBA/2J MGP_DBA2J_G0022520
 protein coding gene Chr16:20435941-20437204 (-)
FVB/NJ MGP_FVBNJ_G0022496
 protein coding gene Chr16:20429723-20430986 (-)
LP/J MGP_LPJ_G0022588
 protein coding gene Chr16:21292586-21293849 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022515
 protein coding gene Chr16:22410711-22411974 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023114
 protein coding gene Chr16:21297389-21298652 (-)
PWK/PhJ MGP_PWKPhJ_G0021685
 protein coding gene Chr16:20708543-20709805 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021516
 protein coding gene Chr16:21032322-21033583 (-)
WSB/EiJ MGP_WSBEiJ_G0021990
 protein coding gene Chr16:21252722-21253984 (-)



Homology
more
  • Human Ortholog
    SST, somatostatin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SST, somatostatin
  • Synonyms
    SMST, SST1
  • Links
    NCBI Gene ID: 6750
    neXtProt AC: NX_P61278
    UniProt: P61278

  • Chr Location
    3q27.3; chr3:187668912-187670394 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 6 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    758 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered GH secretory dynamics, hypergastremia, and reduced hippocampal bursting and excitatory transmission. Mice homozygous for another null allele show impaired motor learning, higher GH and corticosterone levels,gastric fundus hyperplasia and hyperacidity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1816
  • Tissues
    343
  • cDNA Data
    36
  • Literature Summary
    516
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004366 Ensembl Gene Model | MGI Sequence Detail 1386 C57BL/6J ±  kb
    transcript ENSMUST00000004480 Ensembl | MGI Sequence Detail 721 Not Applicable  
    polypeptide ENSMUSP00000004480 Ensembl | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 7
      cDNA 41
      Primer pair 17
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14453
    References
    more
    • Summaries
      All 1356
      Developmental Gene Expression 516
      Gene Ontology 9
      Phenotypes 758
    • Earliest
      J:7362 Shen LP, et al., Sequence of the human somatostatin I gene. Science. 1984 Apr 13;224(4645):168-71
    • Latest
      J:359065 Damborsky JC, et al., Regulation of Hippocamposeptal Synaptic Transmission by GABA(B)Rs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner. J Mol Neurosci. 2024 Aug 30;74(3):82
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory