Sstr2 MGI Mouse Gene Detail - MGI:98328

Symbol

Sstr2
Name

somatostatin receptor 2
Synonyms

Smstr-2, Smstr2, sst2, SSTR-2

Feature Type

protein coding gene
IDs

MGI:98328
NCBI Gene: 20606
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:113510168-113516854 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 79.05 cM
Mapping Data

2 experiments

SNPs within 2kb

290 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98328	protein coding gene	Chr11:113510153-113516854 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019350	protein coding gene	Chr11:117441646-117449962 (+)
A/J	MGP_AJ_G0019318	protein coding gene	Chr11:112384635-112393890 (+)
AKR/J	MGP_AKRJ_G0019287	protein coding gene	Chr11:115690420-115697097 (+)
BALB/cJ	MGP_BALBcJ_G0019292	protein coding gene	Chr11:112793292-112800777 (+)
C3H/HeJ	MGP_C3HHeJ_G0019101	protein coding gene	Chr11:116042566-116049230 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019742	protein coding gene	Chr11:120967545-120976006 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017365	protein coding gene	Chr11:109461775-109468380 (+)
CAST/EiJ	MGP_CASTEiJ_G0018654	protein coding gene	Chr11:117314421-117321079 (+)
CBA/J	MGP_CBAJ_G0019070	protein coding gene	Chr11:125897792-125906087 (+)
DBA/2J	MGP_DBA2J_G0019182	protein coding gene	Chr11:111822580-111829747 (+)
FVB/NJ	MGP_FVBNJ_G0019173	protein coding gene	Chr11:111297244-111304199 (+)
LP/J	MGP_LPJ_G0019252	protein coding gene	Chr11:117879659-117886354 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019204	protein coding gene	Chr11:125050837-125060640 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019779	protein coding gene	Chr11:116345241-116351937 (+)
PWK/PhJ	MGP_PWKPhJ_G0018419	protein coding gene	Chr11:113031143-113038461 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018211	protein coding gene	Chr11:116156193-116162827 (+)
WSB/EiJ	MGP_WSBEiJ_G0018706	protein coding gene	Chr11:116301208-116307878 (+)

Human Ortholog

SSTR2, somatostatin receptor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSTR2, somatostatin receptor 2
Synonyms

SST2
Links

HGNC:11331

NCBI Gene ID: 6752

neXtProt AC: NX_P30874

UniProt: P30874
Chr Location

17q25.1; chr17:73165010-73176633 (+) GRCh38

MGI Vertebrate Homology

Sstr2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SSTR2
Gene Tree

Sstr2

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Phenotype Summary

24 phenotypes from 4 alleles in 5 genetic backgrounds
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show elevated anxiety and locomotor and exploratory deficits. Homozygotes for a reporter allele show altered motor coordination, somatostatin-induced dopamine and glutamate release, retinal rod bipolar cells and EEG patterns, and reduced infarction after focal ischemia.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

75
cDNA Data

12
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sstr2

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All Sequences

37
RefSeq

4
UniProt

1
CCDS

CCDS25598.1, CCDS59571.1

Ensembl

ENSMUSG00000047904 (Evidence)
NCBI Gene

20606

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047904	Ensembl Gene Model \| MGI Sequence Detail	6687	C57BL/6J	± kb
transcript	ENSMUST00000146390	Ensembl \| MGI Sequence Detail	2143	Not Applicable
polypeptide	ENSMUSP00000138101	Ensembl \| MGI Sequence Detail	369	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001669 somatostatin receptor type 2

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR002074 Somatostatin receptor 2

IPR000586 Somatostatin receptor family
GlyGen

P30875 4 sites

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All nucleic 25

Genomic 10

cDNA 12

Primer pair 3

Microarray probesets 5

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MGD-MRK-14455, MGD-MRK-14458

Summaries

All 99

Developmental Gene Expression 15

Gene Ontology 8

Phenotypes 38
Earliest

J:2346 Yamada Y, et al., Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):251-5
Latest

J:348651 Qi L, et al., A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell. 2024 Mar 14;187(6):1508-1526.e16

TSS for Sstr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105751	Chr11:113510144-113510172 (+)	-10 bp
Tssr105752	Chr11:113510206-113510211 (+)	41 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24