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Sod1 Gene Detail
Summary
  • Symbol
    Sod1
  • Name
    superoxide dismutase 1, soluble
  • Synonyms
    B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, Cu/Zn-SOD, CuZnSOD, Ipo-1, Ipo1, Sod-1, SODC
  • Feature Type
    protein coding gene
  • IDs
    MGI:98351
    NCBI Gene: 20655
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90017650-90023221 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.56 cM, cytoband B5-C3
  • Mapping Data
    56 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98351
 protein coding gene Chr16:90017642-90023221 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023024
 protein coding gene Chr16:91140091-91145671 (+)
A/J MGP_AJ_G0022992
 protein coding gene Chr16:86895206-86900785 (+)
AKR/J MGP_AKRJ_G0022962
 protein coding gene Chr16:89501704-89507284 (+)
BALB/cJ MGP_BALBcJ_G0022994
 protein coding gene Chr16:87420949-87426529 (+)
C3H/HeJ MGP_C3HHeJ_G0022755
 protein coding gene Chr16:90065323-90070903 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023441
 protein coding gene Chr16:94102668-94108248 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020943
 protein coding gene Chr16:84614400-84620104 (+)
CAST/EiJ MGP_CASTEiJ_G0022274
 protein coding gene Chr16:90606201-90612048 (+)
CBA/J MGP_CBAJ_G0022724
 protein coding gene Chr16:98093322-98098902 (+)
DBA/2J MGP_DBA2J_G0022858
 protein coding gene Chr16:86800179-86805759 (+)
FVB/NJ MGP_FVBNJ_G0022832
 protein coding gene Chr16:85932241-85937821 (+)
LP/J MGP_LPJ_G0022928
 protein coding gene Chr16:90831078-90836658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022853
 protein coding gene Chr16:102717136-102722716 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023459
 protein coding gene Chr16:90022223-90027803 (+)
PWK/PhJ MGP_PWKPhJ_G0022019
 protein coding gene Chr16:86955723-86961641 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021849
 protein coding gene Chr16:89567132-89572734 (+)
WSB/EiJ MGP_WSBEiJ_G0022326
 protein coding gene Chr16:90256926-90262506 (+)



Homology
more
  • Human Ortholog
    SOD1, superoxide dismutase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOD1, superoxide dismutase 1
  • Synonyms
    ALS, ALS1, HEL-S-44, homodimer, hSod1, IPOA, SOD, STAHP
  • Links
    NCBI Gene ID: 6647
    neXtProt AC: NX_P00441
    UniProt: P00441

  • Chr Location
    21q22.11; chr21:31659666-31668931 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Sod1 mouse models; 18 with human SOD1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    142 phenotypes from 9 alleles in 11 genetic backgrounds
    16 phenotypes from multigenic genotypes
    219 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea. Homozygous KO also causes progressive age-related retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    156
  • GO References
    53
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1487
  • Tissues
    515
  • cDNA Data
    22
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20655 NCBI Gene Model | MGI Sequence Detail 5572 C57BL/6J ±  kb
    transcript NM_011434 RefSeq | MGI Sequence Detail 652 Not Specified  
    polypeptide P08228 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015399 superoxide dismutase [Cu-Zn]
      (term hierarchy)
    • PDB
      3GTT, 3GTV, 3LTV
    • EC
      1.15.1.1
    • InterPro Domains
      IPR001424 Superoxide dismutase, copper/zinc binding domain
      IPR018152 Superoxide dismutase, copper/zinc, binding site
      IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
      IPR036423 Superoxide dismutase-like, copper/zinc binding domain superfamily
    • GlyGen
      P08228 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 5
      cDNA 25
      Primer pair 9
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859
    References
    more
    • Summaries
      All 665
      Developmental Gene Expression 46
      Diseases 6
      Gene Ontology 53
      Phenotypes 219
    • Earliest
      J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
    • Latest
      J:357812 Silva-Hucha S, et al., VEGF expression disparities in brainstem motor neurons of the SOD1(G93A) ALS model: Correlations with neuronal vulnerability. Neurotherapeutics. 2024 Apr;21(3):e00340
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory