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Sos1 Gene Detail
Summary
  • Symbol
    Sos1
  • Name
    SOS Ras/Rac guanine nucleotide exchange factor 1
  • Synonyms
    4430401P03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98354
    NCBI Gene: 20662
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80701181-80787882 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.67 cM, cytoband C3-D
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2330 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98354
 protein coding gene Chr17:80701180-80787882 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024064
 protein coding gene Chr17:83312631-83406925 (-)
A/J MGP_AJ_G0024021
 protein coding gene Chr17:80767903-80857247 (-)
AKR/J MGP_AKRJ_G0023990
 protein coding gene Chr17:82029383-82121225 (-)
BALB/cJ MGP_BALBcJ_G0024023
 protein coding gene Chr17:80633783-80720133 (-)
C3H/HeJ MGP_C3HHeJ_G0023787
 protein coding gene Chr17:82893630-82983458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024467
 protein coding gene Chr17:86351089-86442450 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021908
 protein coding gene Chr17:76113944-76199720 (-)
CAST/EiJ MGP_CASTEiJ_G0023267
 protein coding gene Chr17:83565409-83665484 (-)
CBA/J MGP_CBAJ_G0023761
 protein coding gene Chr17:89963942-90060821 (-)
DBA/2J MGP_DBA2J_G0023890
 protein coding gene Chr17:79257812-79346131 (-)
FVB/NJ MGP_FVBNJ_G0023856
 protein coding gene Chr17:78758402-78844964 (-)
LP/J MGP_LPJ_G0023973
 protein coding gene Chr17:84147906-84239648 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023884
 protein coding gene Chr17:89989946-90086465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024512
 protein coding gene Chr17:82507331-82598759 (-)
PWK/PhJ MGP_PWKPhJ_G0023013
 protein coding gene Chr17:78793502-78891616 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022824
 protein coding gene Chr17:79268046-79376125 (-)
WSB/EiJ MGP_WSBEiJ_G0023334
 protein coding gene Chr17:83326237-83419637 (-)



Homology
more
  • Human Ortholog
    SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
  • Synonyms
    GF1, GGF1, GINGF, HGF, NS4, SOS-1
  • Links
    NCBI Gene ID: 6654
    neXtProt AC: NX_Q07889
    UniProt: Q07889

  • Chr Location
    2p22.1; chr2:38962206-39124868 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sos1 mouse models; 5 with human SOS1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 4 alleles in 5 genetic backgrounds
    17 phenotypes from multigenic genotypes
    5 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant embryos exhibit placental and cardiovascular defects resulting in death around mid-gestation. When heterozygous, these mutations enhance the eye defects of homozygous mutants of the epidermal growth factor receptor gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    63
  • cDNA Data
    18
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20662 NCBI Gene Model | MGI Sequence Detail 86702 C57BL/6J ±  kb
    transcript NM_009231 RefSeq | MGI Sequence Detail 8919 ZRU/MplStud  
    polypeptide Q62245 UniProt | EBI | MGI Sequence Detail 1319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14489, MGI:1918028, MGI:2146862
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 38
      Phenotypes 29
    • Earliest
      J:16346 Bowtell D, et al., Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6511-5
    • Latest
      J:340789 Baltanas FC, et al., Critical requirement of SOS1 for tumor development and microenvironment modulation in KRAS(G12D)-driven lung adenocarcinoma. Nat Commun. 2023 Sep 20;14(1):5856
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory