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Sox11 Gene Detail
Summary
  • Symbol
    Sox11
  • Name
    SRY (sex determining region Y)-box 11
  • Synonyms
    1110038H03Rik, 6230403H02Rik, end1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98359
    NCBI Gene: 20666
  • Alliance
    gene page
  • Transcription Start Sites
    44 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:27384263-27392573 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 9.95 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98359
 protein coding gene Chr12:27384263-27392717 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019639
 protein coding gene Chr12:25120694-25129743 (-)
A/J MGP_AJ_G0019606
 protein coding gene Chr12:24449671-24457995 (-)
AKR/J MGP_AKRJ_G0019577
 protein coding gene Chr12:25222140-25232240 (-)
BALB/cJ MGP_BALBcJ_G0019583
 protein coding gene Chr12:24695242-24704573 (-)
C3H/HeJ MGP_C3HHeJ_G0019387
 protein coding gene Chr12:25130256-25141242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020030
 protein coding gene Chr12:25918494-25929686 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017655
 protein coding gene Chr12:23863438-23871710 (-)
CAST/EiJ MGP_CASTEiJ_G0018942
 protein coding gene Chr12:20107953-20118209 (-)
CBA/J MGP_CBAJ_G0019358
 protein coding gene Chr12:26790459-26801254 (-)
DBA/2J MGP_DBA2J_G0019472
 protein coding gene Chr12:24292087-24300180 (-)
FVB/NJ MGP_FVBNJ_G0019463
 protein coding gene Chr12:24136703-24144817 (-)
LP/J MGP_LPJ_G0019542
 protein coding gene Chr12:25196036-25204359 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019498
 protein coding gene Chr12:26479616-26488977 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020070
 protein coding gene Chr12:24798230-24806546 (-)
PWK/PhJ MGP_PWKPhJ_G0018709
 protein coding gene Chr12:19033069-19041474 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018497
 protein coding gene Chr12:19316227-19326285 (-)
WSB/EiJ MGP_WSBEiJ_G0018993
 protein coding gene Chr12:24994164-25002490 (-)



Homology
more
  • Human Ortholog
    SOX11, SRY-box transcription factor 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX11, SRY-box transcription factor 11
  • Synonyms
    CSS9, IDDMOH, MRD27
  • Links
    NCBI Gene ID: 6664
    neXtProt AC: NX_P35716
    UniProt: P35716

  • Chr Location
    2p25.2; chr2:5692384-5701385 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sox11 mouse models; 1 with human SOX11 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    88 phenotypes from 6 alleles in 8 genetic backgrounds
    69 phenotypes from multigenic genotypes
    5 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with impaired ossification and impaired development of the heart, lung, spleen, stomach, skeleton and pancreas. Mice homozygous for a different knock-out allele exhibit abnormal nervous system development and complete neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1611
  • Tissues
    578
  • cDNA Data
    33
  • Literature Summary
    117
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063632 Ensembl Gene Model | MGI Sequence Detail 8311 C57BL/6J ±  kb
    transcript ENSMUST00000079063 Ensembl | MGI Sequence Detail 8311 Not Applicable  
    polypeptide ENSMUSP00000078070 Ensembl | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 1
      cDNA 38
      Primer pair 20
      Other 12

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-14498, MGI:1913439, MGI:1915029, MGI:2144888
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 117
      Diseases 1
      Gene Ontology 18
      Phenotypes 42
    • Earliest
      J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
    • Latest
      J:352990 Yang J, et al., Spatial transcriptome reveals the region-specific genes and pathways regulated by Satb2 in neocortical development. BMC Genomics. 2024 Aug 2;25(1):757
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory