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Sox5 Gene Detail
Summary
  • Symbol
    Sox5
  • Name
    SRY (sex determining region Y)-box 5
  • Synonyms
    A730017D01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98367
    NCBI Gene: 20678
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:143774151-144727703 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 76.14 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11503 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98367
 protein coding gene Chr6:143774151-144728008 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031474
 protein coding gene Chr6:148712726-149733875 (-)
A/J MGP_AJ_G0031449
 protein coding gene Chr6:142854536-143820322 (-)
AKR/J MGP_AKRJ_G0031377
 protein coding gene Chr6:147090255-148106651 (-)
BALB/cJ MGP_BALBcJ_G0031456
 protein coding gene Chr6:142617717-143581540 (-)
C3H/HeJ MGP_C3HHeJ_G0031178
 protein coding gene Chr6:147116433-148128399 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031918
 protein coding gene Chr6:152735754-153774259 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029042
 protein coding gene Chr6:141633029-142575746 (-)
CAST/EiJ MGP_CASTEiJ_G0030546
 protein coding gene Chr6:146719174-147744611 (-)
CBA/J MGP_CBAJ_G0031138
 protein coding gene Chr6:158544220-159634590 (-)
DBA/2J MGP_DBA2J_G0031295
 protein coding gene Chr6:141665440-142619871 (-)
FVB/NJ MGP_FVBNJ_G0031246
 protein coding gene Chr6:140401097-141362803 (-)
LP/J MGP_LPJ_G0031379
 protein coding gene Chr6:148816697-149832848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031286
 protein coding gene Chr6:162412300-163447825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031950
 protein coding gene Chr6:146937132-147939258 (-)
PWK/PhJ MGP_PWKPhJ_G0030273
 protein coding gene Chr6:140153981-141122773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030097
 protein coding gene Chr6:145107360-146092882 (-)
WSB/EiJ MGP_WSBEiJ_G0030639
 protein coding gene Chr6:147516103-148523899 (-)



Homology
more
  • Human Ortholog
    SOX5, SRY-box transcription factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX5, SRY-box transcription factor 5
  • Synonyms
    LAMSHF, L-SOX5, L-SOX5B, L-SOX5F
  • Links
    NCBI Gene ID: 6660
    neXtProt AC: NX_P35711
    UniProt: P35711

  • Chr Location
    12p12.1; chr12:23529504-24562650 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 5 genetic backgrounds
    24 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice fail to breathe and die at birth exhibiting a narrow thoracic cage, irregularly mineralized sternum, cleft secondary palate, and delayed bone mineralization. Homozygotes for a transposon induced insertion die shortly after birth exhibiting cyanosis and respiratory distress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1084
  • Tissues
    308
  • cDNA Data
    45
  • Literature Summary
    121
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041540 Ensembl Gene Model | MGI Sequence Detail 953553 C57BL/6J ±  kb
    transcript ENSMUST00000038815 Ensembl | MGI Sequence Detail 7243 Not Applicable  
    polypeptide ENSMUSP00000047567 Ensembl | MGI Sequence Detail 763 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 46
      Primer pair 17
      Other 7

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-14506, MGI:2141442, MGI:2442476
    References
    more
    • Summaries
      All 191
      Developmental Gene Expression 121
      Gene Ontology 17
      Phenotypes 29
    • Earliest
      J:1195 Denny P, et al., A conserved family of genes related to the testis determining gene, SRY. Nucleic Acids Res. 1992 Jun 11;20(11):2887
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory