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Src Gene Detail
Summary
  • Symbol
    Src
  • Name
    Rous sarcoma oncogene
  • Synonyms
    pp60c-src
  • Feature Type
    protein coding gene
  • IDs
    MGI:98397
    NCBI Gene: 20779
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157265828-157313758 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.35 cM
  • Mapping Data
    36 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1183 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98397
 protein coding gene Chr2:157260364-157313782 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026782
 protein coding gene Chr2:162422372-162484892 (+)
A/J MGP_AJ_G0026748
 protein coding gene Chr2:155930634-155983587 (+)
AKR/J MGP_AKRJ_G0026719
 protein coding gene Chr2:160527245-160580027 (+)
BALB/cJ MGP_BALBcJ_G0026757
 protein coding gene Chr2:156220721-156273259 (+)
C3H/HeJ MGP_C3HHeJ_G0026499
 protein coding gene Chr2:160832716-160887848 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027206
 protein coding gene Chr2:167257388-167313295 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024576
 protein coding gene Chr2:149384390-149439670 (+)
CAST/EiJ MGP_CASTEiJ_G0025961
 protein coding gene Chr2:161174509-161234620 (+)
CBA/J MGP_CBAJ_G0026476
 protein coding gene Chr2:173262286-173326682 (+)
DBA/2J MGP_DBA2J_G0026614
 protein coding gene Chr2:155107349-155160651 (+)
FVB/NJ MGP_FVBNJ_G0026581
 protein coding gene Chr2:153497464-153550479 (+)
LP/J MGP_LPJ_G0026717
 protein coding gene Chr2:162509994-162568940 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026602
 protein coding gene Chr2:177114775-177171979 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027262
 protein coding gene Chr2:160336091-160396616 (+)
PWK/PhJ MGP_PWKPhJ_G0025695
 protein coding gene Chr2:154625834-154680464 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025498
 protein coding gene Chr2:159283913-159340935 (+)
WSB/EiJ MGP_WSBEiJ_G0026031
 protein coding gene Chr2:161226809-161284424 (+)



Homology
more
  • Human Ortholog
    SRC, SRC proto-oncogene, non-receptor tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRC, SRC proto-oncogene, non-receptor tyrosine kinase
  • Synonyms
    ASV, c-SRC, p60-Src, SRC1, THC6
  • Links
    NCBI Gene ID: 6714
    neXtProt AC: NX_P12931
    UniProt: P12931

  • Chr Location
    20q11.23; chr20:37344685-37406050 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Src mouse models; 7 with human SRC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 4 alleles in 5 genetic backgrounds
    30 phenotypes from multigenic genotypes
    2 images
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    294
  • GO References
    71
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    85
  • cDNA Data
    92
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20779 NCBI Gene Model | MGI Sequence Detail 47931 C57BL/6J ±  kb
    transcript NM_001421000 RefSeq | MGI Sequence Detail 4213 ZRU/MplStud  
    polypeptide P05480 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 6
      cDNA 95
      Primer pair 3
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14556, MGI:2139334
    References
    more
    • Summaries
      All 429
      Developmental Gene Expression 49
      Diseases 1
      Gene Ontology 71
      Phenotypes 100
    • Earliest
      J:5972 Collett MS, et al., Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4
    • Latest
      J:358464 Frampton E, et al., Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced Retinopathy. Am J Pathol. 2024 Sep 25;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory