sy Gene Detail

Summary

• Symbol
  sy
• Name
  shaker-with-syndactylism deletion region

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:98457
  NCBI Gene: 20954
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 18, Syntenic
• Mapping Data
  22 experiments

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  19 phenotypes from 1 allele in 2 genetic backgrounds
  4 phenotypes from multigenic genotypes
  7 phenotype references
  

• All Mutations and Alleles
  1
• Radiation induced
  1
• Find Mice (IMSR)
  2 strains or lines available

Mice homozygous for a radiation-induced deletion die within one month of birth exhibiting syndactylous feet and other skeletal malformations, inner ear dysmorphology, deafness, and abnormal behavior characteristic of vestibular dysfunction.

Sequences &
Gene Models

• NCBI Gene
  20954

Other
Accession IDs

MGD-MRK-14674

References

• Summaries
  All 17

  Diseases 1

  Phenotypes 7
• Earliest
  J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80(1):220-246
• Latest
  J:68881 Chaudhry SS, et al., Mutation of the gene encoding fibrillin-2 results in syndactyly in mice. Hum Mol Genet. 2001 Apr 1;10(8):835-43