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Tap2 Gene Detail
Summary
  • Symbol
    Tap2
  • Name
    transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
  • Synonyms
    Abcb3, Ham-2, Ham2, HAM2, MTP2, PSF2, Tap-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98484
    NCBI Gene: 21355
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34423453-34435295 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98484
 protein coding gene Chr17:34422501-34435295 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023564
 protein coding gene Chr17:34206014-34218634 (+)
A/J MGP_AJ_G0023526
 protein coding gene Chr17:33045157-33058110 (+)
AKR/J MGP_AKRJ_G0023491
 protein coding gene Chr17:33431468-33444238 (+)
BALB/cJ MGP_BALBcJ_G0023530
 protein coding gene Chr17:33210362-33223254 (+)
C3H/HeJ MGP_C3HHeJ_G0023290
 protein coding gene Chr17:33781072-33795332 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023970
 protein coding gene Chr17:35500069-35514288 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021449
 protein coding gene Chr17:30534932-30547958 (+)
CAST/EiJ MGP_CASTEiJ_G0022790
 protein coding gene Chr17:33884437-33897217 (+)
CBA/J MGP_CBAJ_G0023268
 protein coding gene Chr17:36956276-36971432 (+)
DBA/2J MGP_DBA2J_G0023397
 protein coding gene Chr17:32398597-32411326 (+)
FVB/NJ MGP_FVBNJ_G0023363
 protein coding gene Chr17:32259169-32271939 (+)
LP/J MGP_LPJ_G0023474
 protein coding gene Chr17:34475386-34487996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023386
 protein coding gene Chr17:35930252-35945269 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024013
 protein coding gene Chr17:33770848-33783475 (+)
PWK/PhJ MGP_PWKPhJ_G0022540
 protein coding gene Chr17:31332878-31346042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022355
 protein coding gene Chr17:31724043-31738062 (+)
WSB/EiJ MGP_WSBEiJ_G0022851
 protein coding gene Chr17:33807589-33820532 (+)



Homology
more
  • Human Ortholog
    TAP2, transporter 2, ATP binding cassette subfamily B member
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAP2, transporter 2, ATP binding cassette subfamily B member
  • Synonyms
    ABC18, ABCB3, APT2, D6S217E, MHC1D2, PSF-2, PSF2, RING11
  • Links
    NCBI Gene ID: 6891
    neXtProt AC: NX_Q03519
    UniProt: Q03519

  • Chr Location
    6p21.32; chr6:32821831-32838739 (-)  GRCh38
Human Diseases
more
  • Diseases
    18 with human TAP2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have no CD8+ T cells, although their numbers of CD4+ T cells and B cells are normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    63
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    99
  • cDNA Data
    101
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21355 NCBI Gene Model | MGI Sequence Detail 11843 C57BL/6J ±  kb
transcript NM_011530 RefSeq | MGI Sequence Detail 2490 ZRU/MplStud  
polypeptide P36371 UniProt | EBI | MGI Sequence Detail 702 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 108
    Genomic 5
    cDNA 102
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10613, MGD-MRK-10615, MGD-MRK-14713, MGD-MRK-14715, MGI:2146874, MGI:3584394
References
more
  • Summaries
    All 68
    Developmental Gene Expression 5
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
  • Latest
    J:300927 Han X, et al., Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. Elife. 2021 Jan 22;10:e62387
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory