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Tcf7 Gene Detail
Summary
  • Symbol
    Tcf7
  • Name
    transcription factor 7, T cell specific
  • Synonyms
    T cell factor-1, T-cell factor 1, Tcf1, TCF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98507
    NCBI Gene: 21414
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:52143198-52174158 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.86 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    620 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98507
 protein coding gene Chr11:52137347-52174211 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018283
 protein coding gene Chr11:51558112-51588739 (-)
A/J MGP_AJ_G0018252
 protein coding gene Chr11:49629525-49662103 (-)
AKR/J MGP_AKRJ_G0018222
 protein coding gene Chr11:51229630-51260259 (-)
BALB/cJ MGP_BALBcJ_G0018223
 protein coding gene Chr11:49955891-49987027 (-)
C3H/HeJ MGP_C3HHeJ_G0018034
 protein coding gene Chr11:51209764-51240631 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018675
 protein coding gene Chr11:53124289-53155703 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016325
 protein coding gene Chr11:47135562-47166158 (-)
CAST/EiJ MGP_CASTEiJ_G0017599
 protein coding gene Chr11:51227044-51262156 (-)
CBA/J MGP_CBAJ_G0018009
 protein coding gene Chr11:55633927-55665309 (-)
DBA/2J MGP_DBA2J_G0018119
 protein coding gene Chr11:49355830-49388876 (-)
FVB/NJ MGP_FVBNJ_G0018111
 protein coding gene Chr11:49021074-49052352 (-)
LP/J MGP_LPJ_G0018193
 protein coding gene Chr11:51979621-52011121 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018135
 protein coding gene Chr11:56986253-57016913 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018717
 protein coding gene Chr11:51279153-51310101 (-)
PWK/PhJ MGP_PWKPhJ_G0017374
 protein coding gene Chr11:49854010-49884826 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017169
 protein coding gene Chr11:51015182-51045695 (-)
WSB/EiJ MGP_WSBEiJ_G0017646
 protein coding gene Chr11:50900446-50931290 (-)



Homology
more
  • Human Ortholog
    TCF7, transcription factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF7, transcription factor 7
  • Synonyms
    TCF-1
  • Links
    NCBI Gene ID: 6932
    neXtProt AC: NX_P36402
    UniProt: P36402

  • Chr Location
    5q31.1; chr5:134108218-134151865 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in T cell development leading to decreased numbers of T cells in the periphery.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1276
  • Tissues
    420
  • cDNA Data
    84
  • Literature Summary
    88
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000782 Ensembl Gene Model | MGI Sequence Detail 30961 C57BL/6J ±  kb
    transcript ENSMUST00000109071 Ensembl | MGI Sequence Detail 2059 Not Applicable  
    polypeptide ENSMUSP00000104699 Ensembl | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 1
      cDNA 87
      Primer pair 13
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14759, MGI:2144188
    References
    more
    • Summaries
      All 275
      Developmental Gene Expression 88
      Gene Ontology 11
      Phenotypes 120
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:354894 Li Y, et al., Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans. Nat Immunol. 2024 Jul;25(7):1231-1244
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory