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Tcn2 Gene Detail
Summary
  • Symbol
    Tcn2
  • Name
    transcobalamin 2
  • Synonyms
    Tcn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98534
    NCBI Gene: 21452
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3867192-3882159 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.76 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98534
 protein coding gene Chr11:3867077-3882159 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017967
 protein coding gene Chr11:829028-845365 (-)
A/J MGP_AJ_G0017940
 protein coding gene Chr11:850335-865212 (-)
AKR/J MGP_AKRJ_G0017904
 protein coding gene Chr11:879343-894284 (-)
BALB/cJ MGP_BALBcJ_G0017908
 protein coding gene Chr11:814947-831181 (-)
C3H/HeJ MGP_C3HHeJ_G0017721
 protein coding gene Chr11:806154-822747 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018361
 protein coding gene Chr11:902362-922489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016020
 protein coding gene Chr11:747116-762559 (-)
CAST/EiJ MGP_CASTEiJ_G0017283
 protein coding gene Chr11:778133-795806 (-)
CBA/J MGP_CBAJ_G0017696
 protein coding gene Chr11:1106472-1131464 (-)
DBA/2J MGP_DBA2J_G0017807
 protein coding gene Chr11:756551-773270 (-)
FVB/NJ MGP_FVBNJ_G0017798
 protein coding gene Chr11:793818-809167 (-)
LP/J MGP_LPJ_G0017877
 protein coding gene Chr11:911413-932211 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017824
 protein coding gene Chr11:812006-832063 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018400
 protein coding gene Chr11:896557-912221 (-)
PWK/PhJ MGP_PWKPhJ_G0017064
 protein coding gene Chr11:749826-765733 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016860
 protein coding gene Chr11:855344-870535 (-)
WSB/EiJ MGP_WSBEiJ_G0017337
 protein coding gene Chr11:778351-797510 (-)



Homology
more
  • Human Ortholog
    TCN2, transcobalamin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCN2, transcobalamin 2
  • Synonyms
    D22S676, D22S750, II, TC, TC-2, TC2, TC II, TCII
  • Links
    NCBI Gene ID: 6948
    neXtProt AC: NX_P20062
    UniProt: P20062

  • Chr Location
    22q12.2; chr22:30607003-30627271 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TCN2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
This locus controls transcobalamin-2 electrophoretic variation. The s allele determines a slow band in serum from A/J, C57BL/6, BALB/c and C3H/He; the f allele determines faster form in NZB, ST/b and CPB-WV. Heterozygotes have both forms. Sequencing reveals a Gly to Glu substitution in NZB compared to BALB/c, DBA/2 and C57BL/6 (Genbank AF090686).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    172
  • cDNA Data
    390
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020432 Ensembl Gene Model | MGI Sequence Detail 14968 C57BL/6J ±  kb
transcript ENSMUST00000109988 Ensembl | MGI Sequence Detail 1957 Not Applicable  
polypeptide ENSMUSP00000105615 Ensembl | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 390
    cDNA 390

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14807, MGD-MRK-14808, MGI:2144509
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:319903 DiGirolamo PM, et al., Transport of vitamin B12 into mouse leukemia cells. Arch Biochem Biophys. 1975 Jun;168(2):386-93
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory