Trgc1 MGI Mouse Gene Detail - MGI:98625 - T cell receptor gamma, constant 1

Trgc1 Gene Detail

Symbol

Trgc1
Name

T cell receptor gamma, constant 1
Synonyms

Cgamma1, Gm17004, Tcrg-C1

Feature Type

gene segment
IDs

MGI:98625
NCBI Gene: 107573
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:19398273-19400788 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 6.89 cM

SNPs within 2kb

279 from dbSNP Build 142
Strain Annotations

7
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98625	gene segment	Chr13:19398273-19401194 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	MGP_AKRJ_G0002379	gene segment	Chr13:16308233-16317349 (+)
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0002376	gene segment	Chr13:15381206-15386912 (+)
LP/J	MGP_LPJ_G0002418	gene segment	Chr13:16664840-16666965 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0002346	gene segment	Chr13:18065666-18068298 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0002508	gene segment	Chr13:16176413-16181264 (+)
PWK/PhJ	MGP_PWKPhJ_G0002289	gene segment	Chr13:15872864-15875955 (-)
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

TRGC1, T cell receptor gamma constant 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRGC1, T cell receptor gamma constant 1
Synonyms

C1, TCRG, TCRGC1
Links

HGNC:12275

NCBI Gene ID: 6966

UniProt: A2JGV3, P0CF51
Chr Location

7p14.1; chr7:38260088-38265678 (-) GRCh38

Human Ortholog

TRGC2, T cell receptor gamma constant 2
Synonyms

TCRGC2, TRGC2(2X), TRGC2(3X)
Links

HGNC:12276

NCBI Gene ID: 6967

UniProt: P03986
Chr Location

7p14.1; chr7:38239580-38249572 (-) GRCh38

MGI Vertebrate Homology

Trgc1 stringent orthology
2 human;1 mouse
HCOP

vertebrate homology predictions: TRGC1, TRGC2
Gene Tree

Trgc1

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Phenotype Summary

1 phenotype from multigenic genotypes
2 phenotype references

All Mutations and Alleles

1
Targeted

1
Genomic Mutations

1 involving Trgc1
Find Mice (IMSR)

4 strains or lines available

Homozygous null mice lack dendritic epidermal T cells.

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

1
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Expression Atlas

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All Sequences

13
RefSeq

1
UniProt

1

Ensembl

ENSMUSG00000076749 (Evidence)
NCBI Gene

107573

Representative Sequences				Length	Strain/Species	Flank
	genomic	107573	NCBI Gene Model \| MGI Sequence Detail	2516	C57BL/6J	± kb
	polypeptide	A0A075B5Z0	UniProt \| EBI \| MGI Sequence Detail	172	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR003597 Immunoglobulin C1-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR051117 T cell receptor gamma variable/constant region

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All nucleic 12

Genomic 4

cDNA 7

Other 1

Microarray probesets 1

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MGD-MRK-14917, MGI:4440482, MGI:6331303

Summaries

All 20

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 2
Earliest

J:31508 Heilig JS, et al., Diversity of murine gamma genes and expression in fetal and adult T lymphocytes. Nature. 1986 Aug 28-Sep 3;322(6082):836-40
Latest

J:153581 Uche UN, et al., Recombination signal sequence-associated restriction on TCRdelta gene rearrangement affects the development of tissue-specific gammadelta T cells. J Immunol. 2009 Oct 15;183(8):4931-9

TSS for Trgc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118526	Chr13:19397821-19397843 (+)	-441 bp
Tssr118527	Chr13:19398450-19398453 (+)	179 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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