Trgv7 Gene Detail

Summary

• Symbol
  Trgv7
• Name
  T cell receptor gamma, variable 7
• Synonyms
  Tcrg-V7

• Feature Type
  gene segment
• IDs
  MGI:98637
  NCBI Gene: 21641
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr13:19362212-19362662 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 6.89 cM

Strain
Comparison

• SNPs within 2kb
  132 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98637	gene segment	Chr13:19362194-19362662 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0002510	gene segment	Chr13:16285446-16285913 (+)
A/J	MGP_AJ_G0002483	gene segment	Chr13:16070951-16071418 (+)
AKR/J	MGP_AKRJ_G0002469	gene segment	Chr13:16265569-16266037 (+)
BALB/cJ	MGP_BALBcJ_G0002479	gene segment	Chr13:16035539-16036006 (+)
C3H/HeJ	MGP_C3HHeJ_G0002456	gene segment	Chr13:16388067-16388535 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0002604	gene segment	Chr13:16985605-16986073 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002202	gene segment	Chr13:14526264-14526732 (+)
CAST/EiJ	MGP_CASTEiJ_G0002418	gene segment	Chr13:16130377-16130844 (+)
CBA/J	MGP_CBAJ_G0002447	gene segment	Chr13:17549098-17549566 (+)
DBA/2J	MGP_DBA2J_G0002453	gene segment	Chr13:15648743-15649211 (+)
FVB/NJ	MGP_FVBNJ_G0002466	gene segment	Chr13:15336821-15337288 (+)
LP/J	MGP_LPJ_G0002508	gene segment	Chr13:16574662-16575130 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0002436	gene segment	Chr13:17943309-17943777 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0002599	gene segment	Chr13:16075658-16076126 (+)
PWK/PhJ	MGP_PWKPhJ_G0002393	gene segment	Chr13:15686094-15686562 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0002330	gene segment	Chr13:15200690-15201157 (+)
WSB/EiJ	MGP_WSBEiJ_G0002449	gene segment	Chr13:16112159-16112626 (+)

Homology

• Human Ortholog
  TRGV1, T cell receptor gamma variable 1 (non-functional)

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TRGV1, T cell receptor gamma variable 1 (non-functional)
  
• Synonyms
  TCRGV1, V1S1P
• Links
  HGNC:12284

  NCBI Gene ID: 6973

  UniProt: A0A0A0MS02

  
  
• Chr Location
  7p14.1; chr7:38367586-38368169 (-)  GRCh38

---

• Human Ortholog
  TRGV2, T cell receptor gamma variable 2
  
• Synonyms
  TCRGV2, VIS2
• Links
  HGNC:12287

  NCBI Gene ID: 6974

  UniProt: A0A075B6R0

  
  
• Chr Location
  7p14.1; chr7:38362864-38363518 (-)  GRCh38

---

• Human Ortholog
  TRGV3, T cell receptor gamma variable 3
  
• Synonyms
  TCRGV3, V1S3
• Links
  HGNC:12288

  NCBI Gene ID: 6976

  UniProt: P03979

  
  
• Chr Location
  7p14.1; chr7:38358512-38359162 (-)  GRCh38

---

• Human Ortholog
  TRGV4, T cell receptor gamma variable 4
  
• Synonyms
  TCRGV4, V1S4
• Links
  HGNC:12289

  NCBI Gene ID: 6977

  UniProt: A0A0C4DH28

  
  
• Chr Location
  7p14.1; chr7:38353715-38354517 (-)  GRCh38

---

• Human Ortholog
  TRGV5, T cell receptor gamma variable 5
  
• Synonyms
  TCRGV5, V1S5
• Links
  HGNC:12290

  NCBI Gene ID: 6978

  UniProt: A0A0B4J1U4

  
  
• Chr Location
  7p14.1; chr7:38349355-38350022 (-)  GRCh38

---

• Human Ortholog
  TRGV8, T cell receptor gamma variable 8
  
• Synonyms
  TCRGV8, V1S8
• Links
  HGNC:12294

  NCBI Gene ID: 6982

  UniProt: A0A0C4DH27

  
  
• Chr Location
  7p14.1; chr7:38330343-38330935 (-)  GRCh38

---

• MGI Vertebrate Homology
  Trgv7 stringent orthology
  6 human;1 mouse
  
• HCOP
  vertebrate homology predictions: TRGV1, TRGV2, TRGV3, TRGV4, TRGV5, TRGV8
• Gene Tree
  Trgv7
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  5 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  3

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  27
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000076744 (Evidence)
• NCBI Gene
  21641

Representative Sequences			Length	Strain/Species
genomic	21641	NCBI Gene Model | MGI Sequence Detail	451	C57BL/6J
transcript	Z48594	GenBank | ENA | DDBJ | MGI Sequence Detail	305	ABL
polypeptide	A0A0A6YYE8	UniProt | EBI | MGI Sequence Detail	116	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR013106 Immunoglobulin V-set domain
  IPR051117 T cell receptor gamma variable/constant region

Molecular
Reagents

• All nucleic 7

  Genomic 3

  cDNA 3

  Other 1

Other
Accession IDs

MGD-MRK-14929, MGI:6331318

References

• Summaries
  All 10

  Phenotypes 1
• Earliest
  J:30476 Takagaki Y, et al., T cell receptor-gamma and -delta genes preferentially utilized by adult thymocytes for the surface expression. J Immunol. 1989 Mar 15;142(6):2112-21
• Latest
  J:327132 Reis BS, et al., TCR-Vgammadelta usage distinguishes protumor from antitumor intestinal gammadelta T cell subsets. Science. 2022 Jul 15;377(6603):276-284

TSS for Trgv7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118505	Chr13:19362075-19362100 (+)	-124 bp